| Expression of activation-induced cytidine deaminase in ulcerative colitis-associated carcinogenesis. | |
| | |
MedLine Citation:
|
PMID: 22034886 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Gushima M, Hirahashi M, Matsumoto T, Fujita K, Ohuchida K, Oda Y, Yao T, Iida M & Tsuneyoshi M (2011) Histopathology59, 460-469 Expression of activation-induced cytidine deaminase in ulcerative colitis-associated carcinogenesis Aims: Activation-induced cytidine deaminase (AID) is a DNA/RNA-editing enzyme that is essential for hypermutation and class-switch recombination in immunoglobulin genes. The aim of this study was to investigate the expression of AID and its association with p53 mutation in ulcerative colitis (UC)-associated carcinogenesis. Methods and results: The expression of AID was examined in 25 patients with UC-associated neoplasia, 20 UC patients without neoplasia, 18 patients with non-inflamed colorectal mucosa unaffected by UC, and 19 patients with sporadic colorectal cancer, by immunohistochemistry and quantitative reverse transcription polymerase chain reaction analysis. Mutational analysis and immunohistochemistry for p53 were also performed. The degree of AID expression was not different between UC-associated neoplasia and sporadic colorectal cancer. However, AID was expressed in both UC-associated neoplasia and UC without neoplasia. Whereas AID expression in UC-associated neoplasia was not correlated with the grade of dysplasia, expression in non-neoplastic mucosa of UC was correlated with the histological grade of inflammation. In UC-associated neoplasia, there was no significant correlation between AID expression and p53 mutation. Conclusions: AID is associated with inflammation in UC, whereas it may not specifically contribute to carcinogenesis in UC. |
| | |
Authors:
|
Masaki Gushima; Minako Hirahashi; Takayuki Matsumoto; Kouhei Fujita; Kenoki Ohuchida; Yoshinao Oda; Takashi Yao; Mitsuo Iida; Masazumi Tsuneyoshi |
Related Documents
:
|
12341366 - Censuses of population and housing in africa: some issues and problems. 3592336 - Cryptococcal meningitis: initial presentation of acquired immunodeficiency syndrome. 18290906 - The state of health hardware in aboriginal communities in rural and remote australia. 14696696 - The role of non-governmental organizations for the welfare of the elderly: the case of ... 2700506 - Spina bifida today: problems adults face. 7570146 - Chopsticks and suicide. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Histopathology Volume: 59 ISSN: 1365-2559 ISO Abbreviation: Histopathology Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7704136 Medline TA: Histopathology Country: England |
Other Details:
|
Languages: eng Pagination: 460-9 Citation Subset: IM |
Copyright Information:
|
© 2011 Blackwell Publishing Limited. |
Affiliation:
|
Department of Anatomic Pathology Department of Medicine and Clinical Science Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: RNA-binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours.
Next Document: Histopathological predictors of regional lymph node metastasis at the invasive front in early colore...