Document Detail

Expression of WISP3 and RhoC genes at mRNA and protein levels in inflammatory and noninflammatory breast cancer in Tunisian patients.
MedLine Citation:
PMID:  20014943     Owner:  NLM     Status:  MEDLINE    
Previous studies have shown the expression WISP3 and RhoC in cell lines of inflammatory breast cancer (IBC). The aim in the current study was to compare the expression of both genes, in biopsy samples collected from Tunisian patients with localized or metastatic breast cancer and patients with IBC. We investigated 127 patients enrolled in Salah Azaiez Institute in Tunis. Using the RT-PCR, we showed the phenotype (WISP3-, RhoC+) is significantly associated with IBC tumors, while the (WISP3+, RhoC-)phenotype is mostly associated to non-IBC tumors. The frequencies of these tumor phenotypes are significantly different between these tumor groups (p = 10(- 7); relative risk or RR = 3.25; confidential interval or CI 95% = 1.90-5.53). Immunohistochemical test revealing the presence of WISP3 and RhoC proteins correlates with the expression in the biopsy of their encoding genes as detected by RT-PCR. In conclusion, it appears that WISP3 and RhoC genes expression status defines a molecular signature of IBC.
Raja Marrakchi; Ines Khadimallah; Slah Ouerhani; Amor Gamoudi; Fathi Khomsi; Hatem Bouzaine; Mohamed Benamor; Karim Bougatef; Samia Mnif; Rayhana Zitoun; Farouk Benna; Hammouda Boussen; Khaled Rahal; Amel Benammar Elgaaied
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer investigation     Volume:  28     ISSN:  1532-4192     ISO Abbreviation:  Cancer Invest.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-07     Completed Date:  2010-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  399-407     Citation Subset:  IM    
Laboratoire de G?n?tique, Immunologie et Pathologies Humaines, Facult? des Sciences de Tunis, Campus Universitaire, Tunisia.
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MeSH Terms
Breast Neoplasms / chemistry,  metabolism*,  pathology
Insulin-Like Growth Factor Binding Proteins / analysis,  genetics*
Middle Aged
Neoplasm Staging
RNA, Messenger / analysis*
Reverse Transcriptase Polymerase Chain Reaction
rho GTP-Binding Proteins / analysis,  genetics*
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Proteins; 0/RHOC protein, human; 0/RNA, Messenger; 0/WISP3 protein, human; EC GTP-Binding Proteins

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