Document Detail


Expression of TGF, matrix metalloproteinases, and tissue inhibitors in Chinese chronic rhinosinusitis.
MedLine Citation:
PMID:  20392482     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To date there is no information on the expression of mediators associated with tissue remodeling in Asian patients with chronic rhinitis with (CRSwNP) or without (CRSsNP) nasal polyps. OBJECTIVES: To study the expression of TGF-beta1, matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), collagen, and regulatory T cells in Chinese patients with CRSwNP and CRSsNP. METHODS: Thirty-six male and female subjects (12 patients with CRSwNP, 12 patients with CRSsNP, and 12 control subjects), age 17 to 60 years, were recruited into the study. Samples were collected from polyp and sinusoidal mucosal, ethmoidal mucosal, or inferior turbinate in the respective groups and assessed for TGF- beta1, MMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2, TIMP-3, and TIMP-4 by immunoassay; collagen by histochemistry; and forkhead box P3 (FOXP3) mRNA by real-time PCR. RESULTS: Patients with CRSwNP showed significantly lower concentrations of TGF-beta1, TIMP-1, TIMP-4, FOXP3, and collagen compared with patients with CRSsNP. Although there were no significant differences between the concentrations of MMP-7 and MMP-9 in patients with CRSwNP and CRSsNP, these were significantly increased compared with control patients. MMP-2 and TIMP-2 concentrations were not significantly different in any patient group, whereas TIMP-3 was not detectable. CONCLUSION: Chronic rhinosinusitis with nasal polyps is characterized by a relative lack of TGF-ss expression versus CRSsNP. This finding may be causal for decreased collagen, TIMP-1/4, and FOXP3 expression in CRSwNP versus CRSsNP. TGF-ss serves as a main switch for different remodeling patterns in sinus disease.
Authors:
Xiaoyuan Li; Juan Meng; Xiaoming Qiao; Yafeng Liu; Feng Liu; Nan Zhang; Jie Zhang; Gabriele Holtappels; Ba Luo; Peng Zhou; Yongbo Zheng; Ping Lin; Shixi Liu; Claus Bachert
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-14
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  125     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1061-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Affiliation:
Department of Oto-Rhino-Laryngology, West China Medical School, Sichuan University, Chengdu, Sichuan, 610041, China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Asian Continental Ancestry Group*
Chronic Disease
Female
Humans
Male
Matrix Metalloproteinases / metabolism*
Middle Aged
Nasal Polyps / complications,  immunology,  physiopathology
Rhinitis* / complications,  immunology,  physiopathology
Sinusitis* / complications,  immunology,  physiopathology
Tissue Inhibitor of Metalloproteinases / metabolism*
Transforming Growth Factors / metabolism*
Young Adult
Chemical
Reg. No./Substance:
0/Tissue Inhibitor of Metalloproteinases; 76057-06-2/Transforming Growth Factors; EC 3.4.24.-/Matrix Metalloproteinases

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