| Expression of Survivin in pancreatic cancer and its correlation to expression of Bcl-2. | |
| | |
MedLine Citation:
|
PMID: 15309737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: To investigate the expression of Survivin in pancreatic cancer and its correlation to the expression of Bcl-2. METHODS: Survivin and Bcl-2 expressions were examined by immunohistochemistry in 42 tissue samples from pancreatic cancer and 10 from normal pancrease. RESULTS: No survivin expression was detected in the tissue samples from normal pancrease, while it was detected in 34 of 42 tissue samples from pancreatic cancer (81.95%). There was a correlation between survivin expression and differentiation and stages of pancreatic cancer. Survivin positive cases were strongly correlated to Bcl-2 expression (28/30 vs 6/12, P<0.05). CONCLUSION: Overexpression of survivin plays an important role in the development and progression of pancreatic cancer, and correlates to the expression of Bcl-2. Survivin expression can be used as a prognostic factor. |
| | |
Authors:
|
Jian-Guo Qiao; Yu-Qing Zhang; Yu-Chun Yin; Zui Tan |
Related Documents
:
|
11020907 - Pancreatic cancer: current factors and options to determine future research. 924087 - Experimental study of transductal dissemination of cancer of the pancreas. 8665497 - Increased angiogenin expression in pancreatic cancer is related to cancer aggressiveness. 15969757 - The presence of the proteolysis-inducing factor in urine does not predict the malignanc... 23701577 - Coping skills among african-american breast cancer survivors. 20935677 - A positive feedback loop of er-α36/egfr promotes malignant growth of er-negative breas... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: World journal of gastroenterology : WJG Volume: 10 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2004 Sep |
Date Detail:
|
Created Date: 2004-08-13 Completed Date: 2004-12-16 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
|
Languages: eng Pagination: 2759-61 Citation Subset: IM |
Affiliation:
|
Department of General Surgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Cell Differentiation Humans Immunohistochemistry Microtubule-Associated Proteins / metabolism* Middle Aged Neoplasm Proteins Pancreatic Neoplasms / metabolism*, pathology Prognosis Proto-Oncogene Proteins c-bcl-2 / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/BIRC5 protein, human; 0/Microtubule-Associated Proteins; 0/Neoplasm Proteins; 0/Proto-Oncogene Proteins c-bcl-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Simplified purification method for Clostridium difficile toxin A.
Next Document: Effects of Antiadhesion preparation on free fibrinogen and fibrin degrading products in abdominal ex...