| Expression of structural proteins in human female and male genital epithelia and implications for sexually transmitted infections. | |
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MedLine Citation:
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PMID: 21976595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Men and women differ in their susceptibility to sexually transmittable infections (STIs) such as human immunodeficiency virus (HIV). However, a paucity of published information regarding the tissue structure of the human genital tract has limited our understanding of these gender differences. We collected cervical, vaginal, and penile tissues from human adult donors. Tissues were prepared with hematoxylin and eosin stains or immunofluorescence labeling of epithelial cell proteins and were analyzed for structural characteristics. Rhesus macaque genital tissues were evaluated to assess the use of this model for HIV/simian immunodeficiency virus transmission events. We found the stratified squamous epithelia of the male and female genital tract shared many similarities and important distinctions. Expression of E-cadherins, desmogleins 1/2, and involucrin was seen in all squamous epithelia, though expression patterns were heterogeneous. Filaggrin and a true cornified layer were markedly absent in female tissues but were clearly seen in all male epithelia. Desmogleins 1/2 were more consistent in the outermost strata of female squamous genital epithelia. Macaque tissues were similar to their respective human tissues. These initial observations highlight how male and female genital epithelia resemble and differ from one another. Further information regarding tissue structural characteristics will help to understand how STIs traverse these barriers to cause infection. This knowledge will be essential in future HIV pathogenesis, transmission, and prevention studies. |
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Authors:
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Minh H Dinh; Eneniziaogochukwu A Okocha; Ann Koons; Ronald S Veazey; Thomas J Hope |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-02-09 |
Journal Detail:
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Title: Biology of reproduction Volume: 86 ISSN: 1529-7268 ISO Abbreviation: Biol. Reprod. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-10 Completed Date: 2012-07-09 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 0207224 Medline TA: Biol Reprod Country: United States |
Other Details:
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Languages: eng Pagination: 32 Citation Subset: IM |
Affiliation:
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Departments of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. m-dinh@northwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cadherins / metabolism* Desmoglein 1 / metabolism* Desmoglein 2 / metabolism* Disease Susceptibility Epithelium / metabolism Female Genitalia, Female / cytology, metabolism* Genitalia, Male / cytology, metabolism* HIV Infections / transmission Humans Intermediate Filament Proteins / metabolism* Macaca mulatta Male Models, Animal Protein Precursors / metabolism* Sexually Transmitted Diseases / transmission* Simian Acquired Immunodeficiency Syndrome / transmission |
| Grant Support | |
ID/Acronym/Agency:
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5K08HD060451-02/HD/NICHD NIH HHS; 5R33AI076968/AI/NIAID NIH HHS; K08 HD060451/HD/NICHD NIH HHS; U19 AI076981/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cadherins; 0/Desmoglein 1; 0/Desmoglein 2; 0/Intermediate Filament Proteins; 0/Protein Precursors; 0/filaggrin; 60108-77-2/involucrin |
| Comments/Corrections | |
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