Document Detail


Expression of ST13 in colorectal cancer and adjacent normal tissues.
MedLine Citation:
PMID:  15637739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate the in situ expression of suppression of tumorigenecity 13 (ST13) mRNA in both colorectal cancer and adjacent normal tissues.
METHODS: Colorectal cancer cell lines SW1116, SW620 and CoLo205 were enrolled to confirm the feasibility of the in situ hybridization procedure. Seven colorectal cancer and adjacent normal tissues were included for RNA-RNA in situ hybridization.
RESULTS: The expression of ST13 in the seven normal colon tissues was positive and the positive signals appeared in mucosal cells. Only three of the seven colorectal cancer tissues had positive hybridization signals that appeared in adenocarcinoma cells.
CONCLUSION: The expression of ST13 decreases in colorectal cancer tissue compared with that in adjacent normal tissue. ST13 is mostly expressed in colorectal epithelia and adenocarcinoma cells.
Authors:
Lin-Bo Wang; Shu Zheng; Su-Zhan Zhang; Jia-Ping Peng; Feng Ye; Shi-Chang Fang; Jin-Min Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  11     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-07     Completed Date:  2005-02-15     Revised Date:  2014-10-24    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  336-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / metabolism*
Adult
Aged
Carrier Proteins / metabolism*
Cell Line, Tumor
Colon / metabolism*
Colorectal Neoplasms / metabolism*
Feasibility Studies
Humans
In Situ Hybridization
Intestinal Mucosa / metabolism*
Middle Aged
Rectum / metabolism*
Tumor Suppressor Proteins / metabolism*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/ST13 protein, human; 0/Tumor Suppressor Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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