Document Detail


Expression of the SOX10 gene during human development.
MedLine Citation:
PMID:  9720918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SOX10, a new member of the SOX gene family, is a transcription factor defective in the Dom (Dominant megacolon) mouse and in the human Shah-Waardenburg syndrome. To help unravel its physiological role during human development, we studied SOX10 gene expression in embryonic, fetal, and adult human tissues by Northern blot and in situ hybridization. As in mice, the human SOX10 gene was essentially expressed in the neural crest derivatives that contribute to the formation of the peripheral nervous system, and in the adult central nervous system. Nevertheless, it was more widely expressed in humans than in rodents. The spatial and temporal pattern of SOX10 expression supports an important function in neural crest development.
Authors:
N Bondurand; A Kobetz; V Pingault; N Lemort; F Encha-Razavi; G Couly; D E Goerich; M Wegner; M Abitbol; M Goossens
Related Documents :
11170348 - Xpitx1 plays a role in specifying cement gland and head during early xenopus development.
12446188 - Expression of neural cell-adhesion molecule mrna during mouse molar tooth development.
10470498 - Expression of axolotl rna-binding protein during development of the mexican axolotl.
11900458 - Endogenous patterns of bmp signaling during early chick development.
21763428 - A new leukocyte cell-derived chemotaxin-2 from marine fish grouper, epinephelus coioide...
15612948 - Down-regulation of interleukin-1alpha-induced matrix metalloproteinase-13 expression vi...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  432     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-09-18     Completed Date:  1998-09-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  168-72     Citation Subset:  IM    
Affiliation:
Laboratoire de Génétique Moléculaire et Physiopathologie, Institut National de la Santé et de la Recherche Médicale, U.468, Hôpital Henri Mondor, Créteil, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blotting, Northern
Central Nervous System / chemistry,  embryology
DNA-Binding Proteins / genetics*
Embryo, Mammalian / chemistry*
Embryonic and Fetal Development / genetics*
Gene Expression / genetics
High Mobility Group Proteins / genetics*
Humans
In Situ Hybridization
Neural Crest / chemistry,  cytology,  embryology
RNA, Messenger / analysis,  genetics
SOXE Transcription Factors
Tissue Distribution
Transcription Factors / genetics
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/High Mobility Group Proteins; 0/RNA, Messenger; 0/SOX10 protein, human; 0/SOXE Transcription Factors; 0/Sox10 protein, mouse; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lipophilin, a novel heterodimeric protein of human tears.
Next Document:  Alteration of mitochondrial DNA and RNA level in human fibroblasts with impaired vitamin B12 coenzym...