Document Detail

Expression of the SOX10 gene during human development.
MedLine Citation:
PMID:  9720918     Owner:  NLM     Status:  MEDLINE    
SOX10, a new member of the SOX gene family, is a transcription factor defective in the Dom (Dominant megacolon) mouse and in the human Shah-Waardenburg syndrome. To help unravel its physiological role during human development, we studied SOX10 gene expression in embryonic, fetal, and adult human tissues by Northern blot and in situ hybridization. As in mice, the human SOX10 gene was essentially expressed in the neural crest derivatives that contribute to the formation of the peripheral nervous system, and in the adult central nervous system. Nevertheless, it was more widely expressed in humans than in rodents. The spatial and temporal pattern of SOX10 expression supports an important function in neural crest development.
N Bondurand; A Kobetz; V Pingault; N Lemort; F Encha-Razavi; G Couly; D E Goerich; M Wegner; M Abitbol; M Goossens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  432     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-09-18     Completed Date:  1998-09-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  168-72     Citation Subset:  IM    
Laboratoire de Génétique Moléculaire et Physiopathologie, Institut National de la Santé et de la Recherche Médicale, U.468, Hôpital Henri Mondor, Créteil, France.
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MeSH Terms
Blotting, Northern
Central Nervous System / chemistry,  embryology
DNA-Binding Proteins / genetics*
Embryo, Mammalian / chemistry*
Embryonic and Fetal Development / genetics*
Gene Expression / genetics
High Mobility Group Proteins / genetics*
In Situ Hybridization
Neural Crest / chemistry,  cytology,  embryology
RNA, Messenger / analysis,  genetics
SOXE Transcription Factors
Tissue Distribution
Transcription Factors / genetics
Reg. No./Substance:
0/DNA-Binding Proteins; 0/High Mobility Group Proteins; 0/RNA, Messenger; 0/SOX10 protein, human; 0/SOXE Transcription Factors; 0/Sox10 protein, mouse; 0/Transcription Factors

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