Document Detail


Expression of Phaseolus vulgaris leukoagglutinin-binding oligosaccharides in oral squamous cell carcinoma: possible association with the metastatic potential.
MedLine Citation:
PMID:  8905872     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The expression of -GlcNAc beta 1-6Man-(beta 1-6) branched oligosaccharides in carcinoma cells has been considered to influence their metastatic potentials. In the present paper, the lectin histochemistry of oral squamous cell carcinomas obtained in biopsy from 34 patients with Phaseolus vulgaris leukoagglutinin (L-PHA), which potentially binds to N-glycosidic carbohydrates with beta 1-6 linked lactosamin antennae, was studied in order to analyze the relationship between their staining patterns and metastases. The L-PHA-binding oligosaccharides of the carcinomas were expressed on the cell surface in the following patterns: (i) all cells were positive for the staining ('positive'); (ii) some cells were positive but the rest of the carcinoma cells were negative ('weakly positive'); and (iii) all were negative ('negative'). Statistical analysis revealed that the incidence of the metastasis to regional lymph nodes in the 'positive' cases was significantly higher than that in the 'negative' cases. Moreover, the number of the CD14 positive cells including macrophages in the stroma adjacent to the carcinomas in the 'positive' cases was less than that in the 'negative' or 'weakly positive' cases. The expression of L-PHA-binding oligosaccharides in oral squamous cell carcinoma may be responsible for their metastatic potential to regional lymph nodes, possibly including their ability to escape macrophage recognition.
Authors:
N Tanda; S Mori; M Nose; T Saito; S T Song; A Sato; T Teshima
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  46     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-03-07     Completed Date:  1997-03-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  639-45     Citation Subset:  IM    
Affiliation:
Second Department of Oral and Maxillofacial Surgery, Tohoku University, School of Dentistry, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD14 / analysis
Carcinoma, Squamous Cell / metabolism*
Cell Differentiation
Fabaceae
Histocytochemistry
Humans
Lymphatic Metastasis
Mouth Neoplasms / metabolism*
Oligosaccharides / metabolism*
Phytohemagglutinins / metabolism*
Plant Lectins
Plants, Medicinal
Chemical
Reg. No./Substance:
0/Antigens, CD14; 0/Oligosaccharides; 0/Phytohemagglutinins; 0/Plant Lectins; 0/leukoagglutinins, plants

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