Document Detail


Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome.
MedLine Citation:
PMID:  7477118     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Increased levels of P-glycoprotein occur in some osteosarcomas. In this study we determined the relation between P-glycoprotein status and outcome in patients with high-grade osteosarcoma. METHODS: P-glycoprotein status was determined immunohistochemically in specimens of osteosarcoma of the extremities (stage II) from 92 patients who were treated with surgery and chemotherapy. The P-glycoprotein status was analyzed in relation to the length of event-free survival. RESULTS: The presence of increased levels of P-glycoprotein in the osteosarcoma was significantly associated with a decreased probability of remaining event-free after diagnosis (P = 0.002). In a multivariate analysis, P-glycoprotein status (P = 0.001) and the extent of tumor necrosis after preoperative chemotherapy (P = 0.04) were independent predictors of clinical outcome. The risk of adverse events was increased substantially (rate ratio, 3.37; 95 percent confidence interval, 1.60 to 7.10) among patients with increased levels of P-glycoprotein in tumor cells, as compared with patients who did not have increased levels of P-glycoprotein in tumor cells. CONCLUSIONS: In patients with high-grade osteosarcoma treated with surgery and chemotherapy, the presence of increased levels of P-glycoprotein in tumor cells is associated with a significantly increased risk of adverse events and is independent of the extent of necrosis after preoperative chemotherapy.
Authors:
N Baldini; K Scotlandi; G Barbanti-Br?dano; M C Manara; D Maurici; G Bacci; F Bertoni; P Picci; S Sottili; M Campanacci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The New England journal of medicine     Volume:  333     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1995-11-28     Completed Date:  1995-11-28     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1380-5     Citation Subset:  AIM; IM    
Affiliation:
Dipartimento di Oncologia, Istituti Ortopedici Rizzoli, Bologna, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bone Neoplasms / chemistry*,  drug therapy,  pathology,  surgery
Combined Modality Therapy
Disease-Free Survival
Extremities
Female
Humans
Immunohistochemistry
Male
Necrosis
Osteosarcoma / chemistry*,  drug therapy,  pathology,  surgery
P-Glycoprotein / analysis*
Prognosis
Proportional Hazards Models
Chemical
Reg. No./Substance:
0/P-Glycoprotein
Comments/Corrections
Comment In:
N Engl J Med. 1996 May 16;334(20):1335-6; author reply 1336-7   [PMID:  8609959 ]
N Engl J Med. 1996 May 16;334(20):1336; author reply 1336-7   [PMID:  8609960 ]
N Engl J Med. 1996 May 16;334(20):1336; author reply 1336-7   [PMID:  8609961 ]
N Engl J Med. 1995 Nov 23;333(21):1417-9   [PMID:  7477126 ]

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