Document Detail

Expression of O6-methylguanine-deoxyribose nucleic acid methyltransferase and temozolomide response in a patient with a malignant spinal cord astrocytoma. Case report.
MedLine Citation:
PMID:  17542512     Owner:  NLM     Status:  MEDLINE    
The authors report the case of a 28-year-old woman with a high-grade spinal cord astrocytoma. Treatment using surgery, radiation, and temozolomide (TMZ) led to functional recovery and regression of the residual tumor as demonstrated on serial magnetic resonance images. Genetic testing revealed that this tumor did not express the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT). This is the first report in the literature correlating MGMT expression with the clinical response of a high-grade spinal cord astrocytoma treated using TMZ.
Richard A Rovin; Robert Winn
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery. Spine     Volume:  6     ISSN:  1547-5654     ISO Abbreviation:  -     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101223545     Medline TA:  J Neurosurg Spine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  447-50     Citation Subset:  IM    
Upper Michigan Brain Tumor Center, Marquette, Michigan 49855, USA.
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MeSH Terms
Antineoplastic Agents, Alkylating / therapeutic use*
Astrocytoma / drug therapy*,  metabolism*,  surgery
Combined Modality Therapy
Dacarbazine / analogs & derivatives*,  therapeutic use
Magnetic Resonance Imaging
O(6)-Methylguanine-DNA Methyltransferase / metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Spinal Cord Neoplasms / drug therapy*,  metabolism*,  surgery
Reg. No./Substance:
0/Antineoplastic Agents, Alkylating; 4342-03-4/Dacarbazine; 85622-93-1/temozolomide; EC Methyltransferase

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