Document Detail

Expression of MHC class I and II antigens by keratinocytes and enterocytes in acute graft-versus-host disease. Newcastle Bone Marrow Transplant Group.
MedLine Citation:
PMID:  2659108     Owner:  NLM     Status:  MEDLINE    
The expression of MHC class I and subgroups of class II antigens by keratinocytes and enterocytes has been investigated in patients receiving autologous and allogeneic bone marrow transplants. Allogeneic recipients with graft-versus-host disease (GVHD) expressed all the class II antigens HLA DR, DP and DQ more frequently than pretransplant patients, autologous or allogeneic recipients without GVHD post-BMT (p less than 0.01). Staining for DP and DQ was never detected without DR being present. Whenever there was a lymphocytic infiltrate in the epidermis or single cell necrosis in the gut, DR was expressed on the epithelium. There was no difference in class I expression in GVHD. This study further increases the immunopathological characterization of acute GVHD which may improve the understanding of its pathogenesis.
L Sviland; A D Pearson; M A Green; E J Eastham; A J Malcolm; S J Proctor; P J Hamilton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  4     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-07-27     Completed Date:  1989-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
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MeSH Terms
Acute Disease
Bone Marrow Transplantation*
Graft vs Host Disease / immunology*,  pathology
HLA Antigens*
HLA-D Antigens
Middle Aged
Rectum / immunology,  pathology
Skin / immunology,  pathology
Transplantation, Autologous
Transplantation, Homologous
Reg. No./Substance:
0/HLA Antigens; 0/HLA-D Antigens

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