Document Detail


Expression of MHC class I and II antigens by keratinocytes and enterocytes in acute graft-versus-host disease. Newcastle Bone Marrow Transplant Group.
MedLine Citation:
PMID:  2659108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The expression of MHC class I and subgroups of class II antigens by keratinocytes and enterocytes has been investigated in patients receiving autologous and allogeneic bone marrow transplants. Allogeneic recipients with graft-versus-host disease (GVHD) expressed all the class II antigens HLA DR, DP and DQ more frequently than pretransplant patients, autologous or allogeneic recipients without GVHD post-BMT (p less than 0.01). Staining for DP and DQ was never detected without DR being present. Whenever there was a lymphocytic infiltrate in the epidermis or single cell necrosis in the gut, DR was expressed on the epithelium. There was no difference in class I expression in GVHD. This study further increases the immunopathological characterization of acute GVHD which may improve the understanding of its pathogenesis.
Authors:
L Sviland; A D Pearson; M A Green; E J Eastham; A J Malcolm; S J Proctor; P J Hamilton
Related Documents :
9789768 - Relationship between the expression of hla-dr antigen and the effectiveness of preopera...
6166548 - A monoclonal antibody to the hla-dr product recognizes a polymorphic ia determinant in ...
22827328 - Differential expression of hla-a and b-alleles on uveal melanoma as determined by immun...
6184238 - Human t cell clones specific for tetanus toxoid: characterization of antigen specificit...
7227338 - Regional immunologic responses following localized deposition of antigen in the lung.
22822508 - Antibody delivery of drugs and radionuclides: factors influencing clinical pharmacology.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  4     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-07-27     Completed Date:  1989-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
Affiliation:
Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Bone Marrow Transplantation*
Child
Graft vs Host Disease / immunology*,  pathology
HLA Antigens*
HLA-D Antigens
Humans
Middle Aged
Rectum / immunology,  pathology
Skin / immunology,  pathology
Transplantation, Autologous
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/HLA-D Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Report from the International Bone Marrow Transplant Registry. Advisory Committee of the Internation...
Next Document:  Mechanism of graft failure in HLA-matched and HLA-mismatched bone marrow transplant recipients.