| Expression of liver X receptors in pregnancies complicated by preeclampsia. | |
| | |
MedLine Citation:
|
PMID: 20655109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Preeclampsia is a pregnancy-specific disorder associated with hyperlipidemia. Liver X receptor (LXR) alpha and LXRbeta are key regulators of lipid homeostasis. In the current study, we investigated expression of LXRalpha, LXRbeta and their target genes in human term placenta, decidua and subcutaneous adipose tissue from pregnancies complicated by preeclampsia. Furthermore, we analyzed the protein levels of LXRalpha and LXRbeta in placenta. We also analyzed lipid concentrations in term placental tissue. Gene expression of LXRalpha, LXRbeta and fatty acid transporter CD36 was significantly decreased in placental tissues, while increased expression was observed for LXRalpha in adipose tissue, from pregnancies complicated by preeclampsia. The placental protein level of LXRbeta was reduced, and there was a positive correlation between placental LXRbeta mRNA expression and placental free fatty acids in preeclampsia. Our results suggest a possible role for LXRbeta as a transcriptional regulator in preeclampsia. |
| | |
Authors:
|
M S Weedon-Fekjær; G M Johnsen; E H Anthonisen; M Sugulle; H I Nebb; A K Duttaroy; A C Staff |
Related Documents
:
|
19876819 - In preeclampsia, the placenta grows slowly along its minor axis. 2289699 - Maternal serum levels of estriol, prolactin, human placental lactogen and chorionic gon... 8547169 - Placental 11 beta-hydroxysteroid dehydrogenase and the programming of hypertension. 20382879 - Effect of excessive, hormonally induced intrauterine crowding in the gilt on fetal deve... 578679 - Studies on the haemodynamic action of complamin in pregnancy. 19013229 - Development and characterisation of a new model of rat trophoblasts. 2222079 - Therapeutic insemination by donor (tdi) achieves high pregnancy rates in infertile coup... 16802109 - Normal pregnancy outcome in l-2-hydroxyglutaric aciduria. 9806299 - Prognostic factors for an unsatisfactory primary methotrexate treatment of cervical pre... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-22 |
Journal Detail:
|
Title: Placenta Volume: 31 ISSN: 1532-3102 ISO Abbreviation: Placenta Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-06 Completed Date: 2010-12-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
|
Languages: eng Pagination: 818-24 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway. susannew@basalmed.uio.no |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue
/
metabolism Adult Antigens, CD36 / biosynthesis Decidua / metabolism Female Humans Orphan Nuclear Receptors / biosynthesis* Placenta / metabolism* Pre-Eclampsia / metabolism* Pregnancy |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD36; 0/Orphan Nuclear Receptors; 0/liver X receptor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Histologic chorioamnionitis is more common after spontaneous labor than after induced labor at term.
Next Document: Stakeholder views of a mental health court.