Document Detail

Expression of KIR2DL3 and KIR2DS2 natural killer receptors in exercise.
MedLine Citation:
PMID:  21165439     Owner:  NLM     Status:  In-Process    
The mechanisms of early activation of natural killers were studied in volunteers of different athletic qualification. The initial levels of expression of KIR2DL2, PRF1, and GZMB genes regulating the functions of natural killer differ in athletes and untrained subjects. Moderate exercise stimulates transcription activities of these genes. In athletes, the expression increases more intensely than in controls. Stimulation of inhibitory (KIR2DL3) and activation (KIR2DS2) receptors was revealed. This indicated nonspecific stimulation of natural killers, probably mediated by an increase in serum concentration of heat shock protein with a molecular weight of 70 kDa.
V A Shleptsova; E S Grebenyuk; S A Khaustova; N P Obraztsova; M Yu Shkurnikov; D A Sakharov; E A Tonevitsky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  149     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-12-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  755-8     Citation Subset:  IM    
Institute of Physical Culture and Sports, Moscow, Russia.
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