| Expression of IL-1 family members upon stimulation with IL-17 differs in keratinocytes derived from psoriasis patients and healthy donors. | |
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MedLine Citation:
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PMID: 21410667 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: A number of studies have challenged the T cell centred pathogenetic view of psoriasis by the finding that epithelium-expressed genes are intimately involved in the inflammatory process. IL-17 is an important inflammatory mediator in skin psoriasis. Objective: IL-17 is known to act on keratinocytes and we were interested in its impact on expression of pro- and anti-inflammatory IL-1 family members. Methods: We compared human keratinocytes derived from epidermal stem cells of hair follicles plucked from psoriasis patients and healthy individuals using qRT-PCR and ELISA. Results: In the presence of IL-17 psoriasis derived keratinocytes showed a significantly higher induction of the pro-inflammatory members IL-1F6 and IL-1F9 compared with those from healthy individuals but not of anti-inflammatory members IL-1F5, IL-1F7 or IL-1F3. Both basal, as well as IL-17 induced production of IL-1F2 and IL-1F1 were found to be significantly lower in psoriasis keratinocytes. Conclusion: As keratinocytes were derived from epidermal stem cells of the hair follicles and obtained from non-lesional sites, differences found are likely to present an intrinsic feature of psoriasis epithelium. Our data support the significance of IL-1 members as therapeutic targets in psoriasis conditions. |
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Authors:
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P Muhr; J Zeitvogel; I Heitland; T Werfel; M Wittmann |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-17 |
Journal Detail:
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Title: The British journal of dermatology Volume: - ISSN: 1365-2133 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 British Association of Dermatologists. |
Affiliation:
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Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research, Hannover Medical School, Hannover, Germany Department of Experimental Psychology, Faculty of Social Sciences, Utrecht University, Utrecht, The Netherlands Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK. |
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