Document Detail

Expression of a hypoxia-associated protein, carbonic anhydrase-9, correlates with malignant phenotypes of gastric carcinoma.
MedLine Citation:
PMID:  20588040     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Gastric cancers are characterized by a heterogeneously hypoxic environment. Hypoxia might stimulate the malignant potential of cancer cells. The purpose of our study was to clarify the significance of hypoxia in gastric carcinoma by evaluating the expression of a hypoxic marker, namely carbonic anhydrase-9 (CA-9).
METHODS: A total of 265 patients who had undergone a resection of the primary tumor and were confirmed histologically to have sporadic gastric cancer were enrolled in this study. We evaluated the immunohistochemical expression of CA-9 in the paraffin-embedded specimens of 265 gastric adenocarcinomas.
RESULTS: The CA-9 expression was positive in 88 (33%) of 265 gastric carcinomas. The CA-9 expression level was significantly high in cases of type 4 carcinoma (60%, p < 0.001) and diffuse type carcinoma (41%, p < 0.001), and significantly correlated with the invasion depth (p < 0.001), lymph node metastasis (p < 0.001) and lymphatic invasion p = 0.002). The prognosis for CA-9-positive patients was significantly poorer than that of CA-9-negative patients (p = 0.003, log-rank).
CONCLUSION: Hypoxia might be associated with aggressive tumor phenotypes of gastric carcinomas. The hypoxic marker CA-9 may be a useful prognostic indicator.
Yukihiro Kato; Masakazu Yashiro; Satoru Noda; Shinichiro Kashiwagi; Junko Matsuoka; Yuhiko Fuyuhiro; Yosuke Doi; Kosei Hirakawa
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-24
Journal Detail:
Title:  Digestion     Volume:  82     ISSN:  1421-9867     ISO Abbreviation:  Digestion     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-27     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  246-51     Citation Subset:  IM    
Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
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MeSH Terms
Adenocarcinoma / metabolism*,  pathology,  surgery
Carbonic Anhydrases / biosynthesis*
Chi-Square Distribution
Immunoenzyme Techniques
Proportional Hazards Models
Stomach Neoplasms / metabolism*,  pathology,  surgery
Survival Rate
Tumor Markers, Biological / biosynthesis
Reg. No./Substance:
0/Tumor Markers, Biological; EC Anhydrases

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