| Expression of HLA-DR antigen in different histological types of gastric polyp. | |
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MedLine Citation:
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PMID: 1624598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To study the expression of HLA-DR antigen in the different histological types of gastric polyps. METHODS: Ninety five cases of gastric polyps were histologically classified and examined for the presence of Helicobacter pylori, and for degree and type of inflammation. Further sections were stained immunohistochemically for HLA-DR antigen expression in the epithelium using a monoclonal antibody that was reactive to formalin-fixed paraffin wax embedded tissue. RESULTS: HLA-DR antigen was expressed in all of the inflammatory polyps studied (20/20), and in most hyperplastic (12/16) and adenomatous (4/6) polyps. Only a few fundic gland polyps (8/51) stained positively for HLA-DR antigen. Gastric polyps seem to have a greater tendency to express HLA-DR antigens than non-polypoid gastric mucosa, even after considering the factors that may affect HLA-DR antigen expression, such as inflammation and the presence of H pylori. CONCLUSIONS: Growth disturbances/polyp formation may be associated with increased HLA-DR antigen expression. |
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Authors:
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A Wee; M Teh; G C Raju |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pathology Volume: 45 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-08-13 Completed Date: 1992-08-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 509-12 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, National University Hospital, National University of Singapore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Female Gastritis / immunology, microbiology HLA-DR Antigens / analysis* Helicobacter pylori / isolation & purification Humans Immunoenzyme Techniques Infant Male Middle Aged Polyps / immunology* Stomach Neoplasms / immunology* |
| Chemical | |
Reg. No./Substance:
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0/HLA-DR Antigens |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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