| Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active Multiple Sclerosis. | |
| | |
MedLine Citation:
|
PMID: 22278236 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Multiple Sclerosis (MS) is considered to be an autoimmune disease with unknown cause and with immune system dysregulation. Among environmental factors, viruses are most often connected with the etiology of MS.Human Endogenous Retroviruses (HERVs) constitute 5-8% of human genomic DNA and have been detected as transcripts and proteins in the central nervous system (CNS) and peripheral blood, frequently in the context of neuroinflammation. The HERV-Fc1, which belongs to the HERV-H/F family, has received our attention largely because of the genetic association with MS.The authors studied the expression of a capsid (Gag) protein of HERV-H/F origin by flow cytometry in PBMCs from healthy controls and from MS patients with non-active or active disease. There was a significant increase in HERV-H/F Gag expression in CD4+ (P<0.001***) and CD8+ T lymphocytes (P<0.001***), and in monocytes (P=0.0356*) in PBMCs from MS patients with active disease. Furthermore, we have undertaken the first rigorous SYBR green-based absolute Q-PCR evaluation approach to quantify extracellular HERV-Fc1 RNA viral loads in plasma from MS patients and healthy controls. We have found a 4 fold increase in extracellular HERV-Fc1 RNA titers in patients with active MS as compared with healthy controls (P<0.001***). These findings strengthen the link between HERV-Fc1 and the pathology of MS. The cause and biological consequences of these differential expressions will be the subject of further investigation. HERV-Fc1 biology could be a compelling area for understanding the pathology of MS and possibly other autoimmune disorders. |
| | |
Authors:
|
Magdalena Janina Laska; Tomasz Brudek; Kari Konstantin Nissen; Tove Christensen; Møller-Larsen Anné; Thor Petersen; Bjørn Andersen Nexø |
Related Documents
:
|
9543566 - Sucrose permeability as a marker for nsaid-induced gastroduodenal injury. 22249626 - Efficacy and safety of central compartment neck dissection for recurrent thyroid carcin... 21827966 - Measurement of soluble perforin, a marker of cd8(+) t lymphocyte activation in epitheli... 22341206 - Rituximab in central nervous system manifestations of patients with primary sjögren's ... 9347866 - Timing of carotid endarterectomy in patients with recent stroke. 7393376 - Malrecognition of taste in uremia. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
|
Title: Journal of virology Volume: - ISSN: 1098-5514 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0113724 Medline TA: J Virol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
. Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Species specificity of protein kinase R antagonism by cytomegalovirus TRS1 genes.
Next Document: Discovery of seven novel mammalian and avian coronaviruses in Deltacoronavirus supports bat coronavi...