| Expression of Fos within luteinizing hormone-releasing hormone neurons, in relation to the steroid-induced luteinizing hormone surge in guinea pigs. | |
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MedLine Citation:
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PMID: 9475384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The induction of Fos protein was examined within LHRH neurons of guinea pigs; the aim was to delineate relationships between subgroups of LHRH neurons during an LH surge in a laboratory rodent in which the distribution of LHRH neurons and the presence of a true luteal phase in the reproductive cycle resemble those in primates. Approximately one third of the forebrain population of LHRH neurons was examined in ovariectomized steroid-treated guinea pigs killed either before or during a steroid-induced LH surge. LHRH/Fos double-labeled neurons were more abundant in surging compared to presurge guinea pigs (p = 0.008) and were most abundant within the preoptic area and anterior hypothalamus. Nonetheless, double-labeled LHRH/Fos neurons were observed throughout the remainder of the population of LHRH neurons in surging guinea pigs. A relative loss of LHRH reaction product was detected by image analysis in the LHRH terminals in the median eminence of surging guinea pigs, consistent with augmented LHRH release. Thus, there appears to be a coordinated increase in Fos expression in subgroups of LHRH neurons, more pronounced in rostral, as compared to caudal, regions in guinea pigs killed after the peak of the steroid-induced LH surge. |
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Authors:
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J C King; E Liu; P M Ronsheim; M Slonimski; B S Rubin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biology of reproduction Volume: 58 ISSN: 0006-3363 ISO Abbreviation: Biol. Reprod. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-03-30 Completed Date: 1998-03-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0207224 Medline TA: Biol Reprod Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 316-22 Citation Subset: IM |
Affiliation:
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Tufts University School of Medicine, Boston, Massachusetts 02111, USA. jking@opal.tufts.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Gonadotropin-Releasing Hormone / metabolism* Guinea Pigs Image Processing, Computer-Assisted Immunohistochemistry Luteinizing Hormone / blood* Median Eminence / cytology, metabolism Neurons / metabolism* Perfusion Proto-Oncogene Proteins c-fos / biosynthesis* Radioimmunoassay Steroids / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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HD19803/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-fos; 0/Steroids; 33515-09-2/Gonadotropin-Releasing Hormone; 9002-67-9/Luteinizing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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