Document Detail


Expression of FLK1 and CD146 at day 7 following reperfused acute myocardial infarction.
MedLine Citation:
PMID:  20735168     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract Objectives: To investigate the expression of FLK1, CD146 and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction (AMI). Methods: 16 of mini-swines (20 to 30 Kg) were randomly assigned to the sham-operated group and the AMI group. Pathologic myocardial tissue was collected at day 7 following reperfusion and detected by dual immunochemistry, real-time quantitative polymerase chain reaction and western blot. Results: The infarcted area had higher FLK1 mRNA expression than the sham-operated area and the normal area (all P < 0.05), and the infarcted and marginal areas showed higher CD146 protein expression than the sham-operated area (all P < 0.05), but the microvessel density (CD31 positive expression of microvessels/HP) was not significantly different between the infarcted area and the sham-operated area (8.92 ± 3.05 vs 6.43 ± 1.54)(P > 0.05). Conclusion: FLK1 and CD146 expression significantly increase in the infarcted and marginal areas, and the microvessel density of angiogenesis in the infarcted area is similar to normal microvessel density of healthy heart tissue, suggesting that FLK1 and CD146 are possible associated with angiogenesis at day 7 following reperfused acute myocardial infarction.
Authors:
Sheng Kang; Yue-Jin Yang; Yi-Ling Wu; Qing-Zhi Wang; Yue Li; Yi Tian; Yu-Tong Cheng
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Publication Detail:
Type:  Journal Article     Date:  2010-08-24
Journal Detail:
Title:  Cytotherapy     Volume:  13     ISSN:  1477-2566     ISO Abbreviation:  Cytotherapy     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100895309     Medline TA:  Cytotherapy     Country:  England    
Other Details:
Languages:  eng     Pagination:  304-7     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Cardiovascular Institute & Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
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