Document Detail


Expression of Ephs and ephrins in developing mouse inner ear.
MedLine Citation:
PMID:  12684176     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Levels of expression of mRNAs encoding the different Ephs and ephrins were measured by semi-quantitative reverse-transcription polymerase chain reaction in developing mouse whole inner ears, and in dissected fractions of the neonatal mouse inner ear. Nineteen of the 24 known Ephs and ephrins were surveyed. The results showed that between embryonic age (E) 11.5 days and E12.5, levels increased 10-300 times per unit of tissue. In neonatal mice, the fraction containing combined organ of Corti and spiral ganglion showed relatively strong expression of EphA4, EphB3, ephrin-A3, ephrin-B2 and ephrin-B3. In the lateral wall, EphA4, ephrin-A3 and ephrin-B2 were strongly expressed, while ephrin-A3 was particularly strongly expressed in utricular and saccular sensory epithelia. The results suggest that the Ephs and ephrins are likely to play a part in the differentiation of the structures of the inner ear, and show which Ephs and ephrins are most likely to play important roles in the different structures.
Authors:
James O Pickles
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hearing research     Volume:  178     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-09     Completed Date:  2003-12-11     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  44-51     Citation Subset:  IM    
Affiliation:
Vision Touch and Hearing Research Centre, School of Biomedical Sciences, University of Queensland, 4072, Brisbane, Qld, Australia. j.pickles@vthrc.uq.edu.au
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism
Animals
Animals, Newborn / genetics,  metabolism*
Ear, Inner / embryology*,  metabolism*
Embryo, Mammalian / metabolism,  physiology
Embryonic and Fetal Development
Ephrin-A3 / metabolism
Ephrin-B2 / metabolism
Ephrin-B3 / metabolism
Ephrins / metabolism*
Mice
Receptor, EphA1 / metabolism*
Receptor, EphA4 / metabolism
Receptor, EphB3 / metabolism
Tissue Distribution
Chemical
Reg. No./Substance:
0/Ephrin-A3; 0/Ephrin-B2; 0/Ephrin-B3; 0/Ephrins; EC 2.7.10.1/Receptor, EphA1; EC 2.7.10.1/Receptor, EphA4; EC 2.7.10.1/Receptor, EphB3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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