Document Detail


Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53.
MedLine Citation:
PMID:  22999639     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Egr-1 and p53 are involved in pathology of both atherosclerosis and cancer. However, it is unknown whether p53 and Egr1 are interactively involved in apoptosis in atherosclerosis. We found that in human carotid plaques, the expression of p53 was inversely correlated with Egr1. In U937 cells, 7β-hydroxycholesterol and 7-ketocholesterol induced production of reactive oxygen species (ROS), transient up-regulation of Egr1 followed by late induction of p53 and apoptosis. Cells with nuclear fragmentation induced by 7-oxysterol or p53 showed increased levels of p53, but decreased levels of Egr1. In conclusion, ROS induced by 7-oxysterols may function as an early initiator of Egr1 expression. The late induced p53 by 7-oxysterols contributes to apoptotic cell death and is linked to the reduction of Egr1 levels, which resembles the differential expression of p53 and Egr1 in human atheroma progression.
Authors:
Sayem Miah; Shahram Nour Mohammad Zadeh; Xi-Ming Yuan; Wei Li
Related Documents :
22865879 - The liberation of cd44 intracellular domain modulates adenoviral vector transgene expre...
22466889 - Activation-induced cytidine deaminase mrna expression in oral squamous cell carcinoma-d...
12710529 - Angiotensin-ii-induced enhanced expression of gi proteins is attenuated by losartan in ...
22526829 - Phospholipid scramblase 1 expression is enhanced in patients with antiphospholipid synd...
9756539 - Endothelins inhibit the mineralization of osteoblastic mc3t3-e1 cells through the a-typ...
17200439 - The -20 and -217 promoter variants dominate differential angiotensinogen haplotype regu...
16131839 - Antisense knockdown of cyclin e does not affect the midblastula transition in xenopus l...
19465659 - Extracytoplasmic function sigma factors with overlapping promoter specificity regulate ...
16414289 - A cellular model system for expression studies of coagulation proteins.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-19
Journal Detail:
Title:  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie     Volume:  -     ISSN:  1618-1433     ISO Abbreviation:  Exp. Toxicol. Pathol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208920     Medline TA:  Exp Toxicol Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier GmbH. All rights reserved.
Affiliation:
Division of Experimental Pathology, Department of Clinical and Experimental Medicine, Linköping University, Linköping SE-581 85, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Detection of the cytotoxicity of water-insoluble fraction of cigarette smoke by direct exposure to c...
Next Document:  Influence of preparation techniques to the strength of the bone-cement interface behind the flange i...