Document Detail


Expression of EGF, EGF-receptor, p53, v-erb B and ras p21 in colorectal neoplasms by immunostaining paraffin-embedded tissues.
MedLine Citation:
PMID:  7912978     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunohistochemical studies were performed to clarify the significance of the expression or overexpression of epidermal growth factor (EGF), EGF-receptor (EGFR), p53, v-erb B, ras p21 in 23 cases each of tubular adenoma and adenocarcinoma. The expression of EGF, EGFR, p53, v-erb B, and ras p21 in paraffin-embedded tissues, from 46 patients with colorectal tumors (adenoma: 23 cases; 14 mild dysplasia, six moderate dysplasia, three severe dysplasia, adenocarcinoma: 23 cases; 17 well differentiated, two moderately differentiated, three poorly differentiated, one mucinous carcinoma was analyzed immunohistochemically using anti-EGF, EGFR, p53, v-erb B and ras p21 antibodies. The EGF and ras p21 tended to express more strongly in carcinoma cases than in the adenoma cases, and in severe and moderate dysplasia than in mild dysplasia (EGF: stained positive in five adenomas [21.74%] and 17 adenocarcinomas [73.91%]; ras p21: stained positive in six adenomas [26.09%] and 14 adenocarcinomas [60.87%]. The EGFR stained positive in two adenomas (8.70%) and two adenocarcinomas (8.70%). The p53 and v-erb B showed positive staining only in the carcinoma cases (p53: stained positive in four cases [17.39%]; v-erb B: stained positive in eight cases [34.78%]). This study suggests that these factors seem to have some role in the progression of colon neoplasms. It suggests that genetic alteration is not always equal to the overexpression of protein products, but that it reflects them well, and that the staining makes some contribution to differential diagnosis in colorectal neoplasms.
Authors:
Y Hayashi; Y W Widjono; K Ohta; K Hanioka; C Obayashi; K Itoh; Y Imai; H Itoh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pathology international     Volume:  44     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-08-09     Completed Date:  1994-08-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  124-30     Citation Subset:  IM    
Affiliation:
First Department of Pathology, Kobe University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / chemistry,  pathology
Adenoma / chemistry,  pathology
Adult
Aged
Aged, 80 and over
Colorectal Neoplasms / chemistry*,  pathology*
Epidermal Growth Factor / analysis
Female
Humans
Immunohistochemistry
Male
Middle Aged
Neoplasm Proteins / analysis*
Neoplasms, Glandular and Epithelial / chemistry*,  pathology*
Oncogene Proteins v-erbB
Precancerous Conditions / chemistry,  pathology
Proto-Oncogene Proteins p21(ras) / analysis
Receptor, Epidermal Growth Factor / analysis
Retroviridae Proteins, Oncogenic / analysis
Tumor Suppressor Protein p53 / analysis
Chemical
Reg. No./Substance:
0/Neoplasm Proteins; 0/Oncogene Proteins v-erbB; 0/Retroviridae Proteins, Oncogenic; 0/Tumor Suppressor Protein p53; 62229-50-9/Epidermal Growth Factor; EC 2.7.10.1/Receptor, Epidermal Growth Factor; EC 3.6.5.2/HRAS protein, human; EC 3.6.5.2/Proto-Oncogene Proteins p21(ras)

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