| Expression of E-cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo. | |
| | |
MedLine Citation:
|
PMID: 10069537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We examined the expression of E-cadherin in nine oral cancer cell lines. HSC-4, NA, ZA, HOC927 and Ca9-22 cells strongly expressed E-cadherin [E-CD(++) cell line] and HSC-2 and HSC-3 cells weakly expressed E-cadherin [E-CD(+) cell line]. All the cell lines that expressed E-cadherin were of cuboidal morphology and formed cobblestone colonies. In contrast, TSU and HOC313 cells had spindle shapes, formed dispersed colonies, and were completely negative for E-cadherin [E-CD(-) cell line]. Moreover, all cell lines that expressed E-cadherin showed tumorgenicity in SCID mice, but E-CD(-) cell lines did not show tumorgenicity. The tumors derived from E-CD(+) cell lines invaded deeper into the connective tissues than those from E-CD(++) cell lines. In immunohistochemical analysis, the difference was more marked at the edges of the cancer nests. These results suggest that E-cadherin expression was relevant to the cell forms and the differential grade of cultured cells and that reduced E-cadherin in oral cancer may be associated with invasiveness in vivo. |
| | |
Authors:
|
T Hoteiya; E Hayashi; K Satomura; N Kamata; M Nagayama |
Related Documents
:
|
6960647 - Enzyme histochemical studies of the homogeneity of the mononuclear phagocyte system wit... 604697 - Distribution of glycoconjugates in mouse fibroblasts with varying degrees of tumorigeni... 11424177 - Role of glutathione s-transferase mu (gstm1) in styrene-7,8-oxide toxicity and mutageni... 2886027 - Identification of continuous green monkey spleen cell line 455. 16085357 - Elevated phosphorylation of chk1 and decreased phosphorylation of chk2 are associated w... 15144867 - Iris pigment epithelial cells: a possible cell source for the future treatment of neuro... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology Volume: 28 ISSN: 0904-2512 ISO Abbreviation: J. Oral Pathol. Med. Publication Date: 1999 Mar |
Date Detail:
|
Created Date: 1999-04-14 Completed Date: 1999-04-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8911934 Medline TA: J Oral Pathol Med Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 107-11 Citation Subset: D; IM |
Affiliation:
|
First Department of Oral and Maxillofacial Surgery, School of Dentistry, Tokushima University, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cadherins / metabolism* Carcinoma, Squamous Cell / chemistry, metabolism*, pathology Cell Line Humans Immunoblotting Immunohistochemistry Mice Mice, SCID Mouth Neoplasms / chemistry, metabolism*, pathology Neoplasm Invasiveness* Neoplasm Proteins / metabolism* Tumor Cells, Cultured / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Cadherins; 0/Neoplasm Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: DNA alterations in human oral squamous cell carcinomas detected by restriction landmark genomic scan...
Next Document: The in vitro post-antifungal effect of nystatin on Candida species of oral origin.