Document Detail


Expression of E-Cadherin and α-Catenin in T1 N0 Laryngeal Cancer.
MedLine Citation:
PMID:  23225423     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
MATERIALS AND METHODS: Fifty-five T1 N0 laryngeal biopsies were tested by immunohistochemistry for the E-cadherin/α-catenin adhesion complex.
RESULTS: High immunohistochemical expression of E-cadherin and α-catenin was found in 18% and 53% cases, respectively. Expression of both adhesion molecules decreased according to histological grading; a significant relationship was particularly found between high E-cadherin expression and G1 cases (p=0.013). High E-cad-herin expression was statistically associated with in situ carcinoma (p=0.006). Non-statistical significance was evidenced between these adhesion molecules and tobacco use or site of occurence. Regarding clinical outcome, recurrence was associated with low expression of both adhesion molecules.
CONCLUSION: E-cadherin and α-catenin down-regulation might be associated with neoplastic transformation in laryngeal tissues and might be regarded as a risk factor for clinical recurrence.
Authors:
Elisabetta Carico; Marco Radici; Nunzia Simona Losito; Salvatore Raffa; Luca Firrisi; Alfredo Fabiano; Marco Manola; Aldo Vecchione; Maria Rosaria Giovagnoli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  32     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  5245-9     Citation Subset:  IM    
Affiliation:
Department of Clinical and Molecular Medicine, Sapienza University, A.O. Sant'Andrea, Via di Grottarossa 1035, 00198 Rome, Italy. elisabetta.carico@uniroma1.it.
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