| Expression of E-Cadherin and α-Catenin in T1 N0 Laryngeal Cancer. | |
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MedLine Citation:
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PMID: 23225423 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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MATERIALS AND METHODS: Fifty-five T1 N0 laryngeal biopsies were tested by immunohistochemistry for the E-cadherin/α-catenin adhesion complex. RESULTS: High immunohistochemical expression of E-cadherin and α-catenin was found in 18% and 53% cases, respectively. Expression of both adhesion molecules decreased according to histological grading; a significant relationship was particularly found between high E-cadherin expression and G1 cases (p=0.013). High E-cad-herin expression was statistically associated with in situ carcinoma (p=0.006). Non-statistical significance was evidenced between these adhesion molecules and tobacco use or site of occurence. Regarding clinical outcome, recurrence was associated with low expression of both adhesion molecules. CONCLUSION: E-cadherin and α-catenin down-regulation might be associated with neoplastic transformation in laryngeal tissues and might be regarded as a risk factor for clinical recurrence. |
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Authors:
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Elisabetta Carico; Marco Radici; Nunzia Simona Losito; Salvatore Raffa; Luca Firrisi; Alfredo Fabiano; Marco Manola; Aldo Vecchione; Maria Rosaria Giovagnoli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 32 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 5245-9 Citation Subset: IM |
Affiliation:
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Department of Clinical and Molecular Medicine, Sapienza University, A.O. Sant'Andrea, Via di Grottarossa 1035, 00198 Rome, Italy. elisabetta.carico@uniroma1.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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