Document Detail


Expression of decoy receptor 3 in diffuse sclerosing variant of papillary thyroid carcinoma: correlation with M2 macrophage differentiation and lymphatic invasion.
MedLine Citation:
PMID:  23186064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is a unique variant of PTC that is characterized by extensive lymphovascular invasion of tumor cells in a background of lymphocytic thyroiditis. The lymphatic emboli contain tumor cells as well as macrophages, but the recruitment of these macrophages is not well understood. The aim of this study was to determine the relationship between the expression of Decoy receptor 3 (DcR3), the recruitment of tumor-associated macrophages (TAMs), and lymphatic invasion in DSV-PTC.
METHODS: We retrospectively examined 14 cases of DSV-PTC using immunohistochemistry studies. The density of TAMs, lymphatic vessel density, lymphatic invasion, tumor emboli area, and DcR3 expression were assessed. Statistical analyses were performed using Fisher's exact test, unpaired t-test, and linear regression.
RESULTS: The lymphatic tumor emboli contained a relatively higher density of TAMs than stroma and classical PTC (CPTC) areas. In addition, the number of lymphatic invasions and the size of the tumor emboli area were positively correlated with the number of M2 TAMs. A higher density of M2 TAMs was associated with older patients and larger tumor size. Moreover, DcR3 was expressed only in lymphatic tumor cells and squamous metaplastic tumor cells, but not in macrophages and CPTC. In addition, the preferential expression of DcR3 in tumors was associated with higher levels of M2 TAMs and lymphatic invasion.
CONCLUSION: Despite the fact that the exact relationship between DcR3, M2 macrophages, and lymphatic invasion in DSV-PTC remains to be elucidated, our findings suggest that DcR3 expression in DSV-PTC tumor cells may promote the polarized macrophage differentiation toward the M2 phenotype. This phenomenon may further promote lymphatic invasion of DSV-PTC tumor cells.
Authors:
Wei-Chin Chang; Jui-Yu Chen; Chen-Hsen Lee; An-Hang Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-05-28
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  23     ISSN:  1557-9077     ISO Abbreviation:  Thyroid     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-07     Completed Date:  2014-01-28     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  720-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Carcinoma / immunology,  metabolism,  pathology
Carcinoma, Papillary / immunology,  metabolism*,  pathology,  secondary
Cell Differentiation
Female
Follow-Up Studies
Humans
Lymphatic Metastasis
Macrophages / pathology*
Male
Middle Aged
Neoplasm Proteins / metabolism*
Receptors, Tumor Necrosis Factor, Member 6b / metabolism*
Retrospective Studies
Sclerosis
Thyroid Gland / immunology,  metabolism*,  pathology
Thyroid Neoplasms / immunology,  metabolism*,  pathology
Tumor Burden
Chemical
Reg. No./Substance:
0/Neoplasm Proteins; 0/Receptors, Tumor Necrosis Factor, Member 6b; 0/TNFRSF6B protein, human
Comments/Corrections

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