Document Detail

Expression of CD44 in canine mammary tumours.
MedLine Citation:
PMID:  19592009     Owner:  NLM     Status:  MEDLINE    
CD44 is an important adhesion molecule for hyaluronan, a major component of the extracellular matrix (ECM). In human breast cancer, the interaction of tumour cells with the ECM via CD44 is favoured as a major candidate for tumour progression and metastasis. The present study was designed to investigate immunohistochemically the expression of the standard form of CD44 in normal, hyperplastic and neoplastic canine mammary tissue. CD44 was expressed in normal and hyperplastic mammary tissue predominantly by ductal and alveolar epithelial cells and to a minor extent by myoepithelial cells. Stromal cells and blood vessels displayed low to moderate CD44 expression. In simple and complex adenomas and benign mixed tumours there was significant up-regulation of CD44 expression in alveolar epithelial cells compared with adjacent non-neoplastic mammary tissue. Peripheral epithelial cells of simple and complex adenomas, benign mixed tumours and complex carcinomas expressed significantly more CD44 compared with adjacent non-neoplastic mammary tissue. Peripheral epithelial cells of simple adenomas revealed a significantly higher CD44 expression compared with simple carcinomas. A statistical trend to greater CD44 expression was found in peripheral epithelial cells of complex adenomas, benign mixed tumours and complex carcinomas compared with simple carcinomas. Up-regulation of CD44 therefore appears to be associated with benign or relatively benign biological behaviour of canine mammary tumours.
V Paltian; S Alldinger; W Baumg??rtner; P Wohlsein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-09
Journal Detail:
Title:  Journal of comparative pathology     Volume:  141     ISSN:  1532-3129     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-16     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  237-47     Citation Subset:  IM    
Department of Pathology, University of Veterinary Medicine, D-30559 Hannover, Germany.
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MeSH Terms
Adenoma / metabolism*,  pathology
Analysis of Variance
Antigens, CD44 / metabolism*
Carcinoma / metabolism*,  pathology
Dog Diseases*
Mammary Glands, Animal / metabolism,  pathology
Mammary Neoplasms, Animal / metabolism*,  pathology
Neoplasm Staging
Statistics, Nonparametric
Reg. No./Substance:
0/Antigens, CD44

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