| Expression of CD34, alpha-smooth muscle actin and transforming growth factor-beta1 in squamous intraepithelial lesions and squamous cell carcinoma of the cervix. | |
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MedLine Citation:
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PMID: 19383239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This retrospective study investigated CD34, alpha-smooth muscle actin (alpha-SMA), and transforming growth factor-beta1 (TGF-beta1) expression in stromal cells of cervical intraepithelial neoplasias (CINs; n = 30), invasive cervical squamous cell carcinomas (SCCs; n = 38) and adjacent normal cervix. Normal cervix and CINs contained diffuse CD34-positive stromal cells but no alpha-SMA-positive myofibroblasts. In contrast, 34 of 38 SCCs were free of CD34-positive stromal cells and all contained alpha-SMA-positive stromal myofibroblasts; adjacent normal tissue contained CD34-positive stromal cells and no alpha-SMA-positive myofibroblasts. More intense TGF-beta1 expression was observed in SCC cells than in normal cervical epithelium or CINs. This study shows that the disappearance of CD34-positive stromal cells and appearance of alpha-SMA-positive stromal myofibroblasts may be associated with transformation of cervical CIN to SCC. These findings support the suggestion that over-production of TGF-beta1 in SCC cells is one potential mechanism mediating the transformation of stromal cells to myofibroblasts in cervical carcinogenesis. |
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Authors:
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Q Li; W Huang; X Zhou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of international medical research Volume: 37 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2009 Mar-Apr |
Date Detail:
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Created Date: 2009-04-22 Completed Date: 2009-06-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
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Languages: eng Pagination: 446-54 Citation Subset: IM |
Affiliation:
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Department of Pathology, Clinical School of Medical College of Nanjing University, Nanjing Jinling Hospital, Nanjing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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metabolism* Adult Aged Antigens, CD34 / metabolism* Carcinoma, Squamous Cell / metabolism* Cervical Intraepithelial Neoplasia / metabolism* Epithelial Cells / metabolism, pathology Female Humans Middle Aged Myocytes, Smooth Muscle / metabolism*, pathology Stromal Cells / metabolism, pathology Transforming Growth Factor beta1 / metabolism* Uterine Cervical Neoplasms / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Antigens, CD34; 0/Transforming Growth Factor beta1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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