Document Detail


Expression of CD34, alpha-smooth muscle actin and transforming growth factor-beta1 in squamous intraepithelial lesions and squamous cell carcinoma of the cervix.
MedLine Citation:
PMID:  19383239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This retrospective study investigated CD34, alpha-smooth muscle actin (alpha-SMA), and transforming growth factor-beta1 (TGF-beta1) expression in stromal cells of cervical intraepithelial neoplasias (CINs; n = 30), invasive cervical squamous cell carcinomas (SCCs; n = 38) and adjacent normal cervix. Normal cervix and CINs contained diffuse CD34-positive stromal cells but no alpha-SMA-positive myofibroblasts. In contrast, 34 of 38 SCCs were free of CD34-positive stromal cells and all contained alpha-SMA-positive stromal myofibroblasts; adjacent normal tissue contained CD34-positive stromal cells and no alpha-SMA-positive myofibroblasts. More intense TGF-beta1 expression was observed in SCC cells than in normal cervical epithelium or CINs. This study shows that the disappearance of CD34-positive stromal cells and appearance of alpha-SMA-positive stromal myofibroblasts may be associated with transformation of cervical CIN to SCC. These findings support the suggestion that over-production of TGF-beta1 in SCC cells is one potential mechanism mediating the transformation of stromal cells to myofibroblasts in cervical carcinogenesis.
Authors:
Q Li; W Huang; X Zhou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  37     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2009 Mar-Apr
Date Detail:
Created Date:  2009-04-22     Completed Date:  2009-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  446-54     Citation Subset:  IM    
Affiliation:
Department of Pathology, Clinical School of Medical College of Nanjing University, Nanjing Jinling Hospital, Nanjing, China.
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism*
Adult
Aged
Antigens, CD34 / metabolism*
Carcinoma, Squamous Cell / metabolism*
Cervical Intraepithelial Neoplasia / metabolism*
Epithelial Cells / metabolism,  pathology
Female
Humans
Middle Aged
Myocytes, Smooth Muscle / metabolism*,  pathology
Stromal Cells / metabolism,  pathology
Transforming Growth Factor beta1 / metabolism*
Uterine Cervical Neoplasms / metabolism*
Chemical
Reg. No./Substance:
0/Actins; 0/Antigens, CD34; 0/Transforming Growth Factor beta1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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