Document Detail

Expression of CD31 by cells of extensive ductal in situ and invasive carcinomas of the breast.
MedLine Citation:
PMID:  11400156     Owner:  NLM     Status:  MEDLINE    
CD31, an adhesion molecule expressed by endothelial cells, leukocytes, and platelets, is used in surgical pathology as a marker of normal and neoplastic vascularization. During the assessment of angiogenesis in breast carcinomas, CD31 expression was observed in a single case of large (5.2 cm diameter) high nuclear grade ductal carcinoma in situ (HG-DCIS) associated with poorly differentiated invasive ductal carcinoma (G3-IDC). Expression was limited to the cell membrane. This study focused on 32 HG-DCIS> or = 2 cm, either pure or associated with IDC. Cancer cells wereCD31(+) in 11 cases. Double staining using anti-CD31 monoclonal antibody (MAb) and anti-CD44 MAb, the anti-hyaluronate receptor, showed that foci of CD31(+) and CD44(-) tumour cells could be traced throughout the glandular tree, marking the intraductal diffusion of tumour up to Paget's cells at the nipple. The associated G3-IDC and their lymph node metastases were instead CD31(+) and CD44(+). CD31(+) tumours were oestrogen receptor (ER)(-), frequently p53(+) and c-erb-B2(+), and infiltrated by CD4(+) T lymphocytes. Normal and hyperplastic epithelia were constantly CD31(-). Other endothelial markers (e.g Factor VIII-RA and CD34) were not expressed by carcinoma cells, as was CD38, the CD31 ligand. In conclusion, CD31 expression is a feature acquired by breast cancer cells in the DCIS model. CD31 expression mainly correlates with tumour cells spreading within the ductal system. Finally, the invasive phenotype requires the co-expression of CD31 and CD44.
A Sapino; M Bongiovanni; P Cassoni; L Righi; R Arisio; S Deaglio; F Malavasi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pathology     Volume:  194     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-11     Completed Date:  2001-06-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  254-61     Citation Subset:  IM    
Copyright Information:
Copyright 2001 John Wiley& Sons, Ltd.
Department of Biomedical Sciences and Human Oncology, University of Torino Medical School, Torino, Italy.
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MeSH Terms
Aged, 80 and over
Antigens, CD31 / analysis*
Antigens, CD44 / analysis
Anus Neoplasms / immunology
Breast Neoplasms / blood supply,  immunology*
Carcinoma in Situ / blood supply,  immunology*
Carcinoma, Ductal, Breast / blood supply,  immunology*
Case-Control Studies
Middle Aged
Neovascularization, Pathologic*
Paget Disease Extramammary / immunology
Paget's Disease, Mammary / immunology
Tumor Markers, Biological / analysis
Vulvar Neoplasms / immunology
Reg. No./Substance:
0/Antigens, CD31; 0/Antigens, CD44; 0/Tumor Markers, Biological
Comment In:
J Pathol. 2002 Mar;196(3):364; author reply 364-5   [PMID:  11857502 ]

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