Document Detail


Expression of CD147 and monocarboxylate transporters MCT1, MCT2 and MCT4 in porcine small intestine and colon.
MedLine Citation:
PMID:  16901736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lactate, formed mainly in the stomach and small intestines, and short-chain fatty acids (SCFAs) formed in the colon, are ionised and require transporter proteins such as monocarboxylate transporters (MCTs) for absorption. The amounts of MCT1, MCT2, MCT4 and CD147, an ancillary protein for MCT1 and MCT4, were measured by immunoblotting the small intestine and colon of 40 pigs (Landrace, Yorkshire and LandracexYorkshire). MCT1 and MCT4 were found in both small intestine and colon, but MCT2 only in the small intestine. In both small intestine and colon, Yorkshire pigs had more CD147 than Landrace pigs, while no interbreed differences were found in MCT isoforms. Since CD147 is essential for the activity of MCT1 and MCT4, the breed difference suggests that MCT activity is higher in Yorkshire than in Landrace pigs. The absence of MCT2 in the colon suggests that it is mainly a lactate transporter, while MCT1 and MCT4 facilitate the transport of both lactate and SCFA.
Authors:
K Sepponen; M Ruusunen; J A Pakkanen; A R Pösö
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-09
Journal Detail:
Title:  Veterinary journal (London, England : 1997)     Volume:  174     ISSN:  1090-0233     ISO Abbreviation:  Vet. J.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-12     Completed Date:  2007-09-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706281     Medline TA:  Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  122-8     Citation Subset:  IM    
Affiliation:
Department of Basic Veterinary Sciences, P.O. Box 66, University of Helsinki, Helsinki, Finland. katri.sepponen@helsinki.fi
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Antigens, CD147 / biosynthesis*
Female
Intestinal Absorption
Intestine, Small / metabolism*
Male
Molecular Sequence Data
Monocarboxylic Acid Transporters / biosynthesis*
Swine / metabolism*
Chemical
Reg. No./Substance:
0/Monocarboxylic Acid Transporters; 136894-56-9/Antigens, CD147

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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