Document Detail


Expression of B-myb in neuroblastoma tumors is a poor prognostic factor independent from MYCN amplification.
MedLine Citation:
PMID:  10416595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The transcription factors of the Myb family are expressed in several tissues and play an important role in cell proliferation, differentiation, and survival In this study, the expression of A-myb, B-myb, and c-myb was investigated in a group of 64 neuroblastomas at different dinical stages by a sensitive reverse transcription-PCR tchnique and correlated with patients' survival. All of the myb genes were frequently expressed in neuroblastoma tumors. Interestingly, the expression of B-myb, which was detected in 33 cases, was associated with an increased risk of death (P = 0.027 in a univariate analysis), whereas there was no correlation with A-myb and c-myb expression. In addition, in a multivariate Cox regression analysis that included myb gene expression, MYCN status, age at diagnosis, and tumor staging, MYCN amplification and B-myb expression were independently associated to an increased risk (P < 0.01 and P = 0.015, respectively). In overall survival curves obtained by stratifying the neuroblastoma cases on the basis of MYCN status and B-myb expression, the group of patients without MYCN amplification and positive for B-myb expression had worse survival probability than that without MYCN amplification and nonexpressing B-myb (P < 0.01). In summary, these findings provide the first demonstration that B-myb expression can be a useful prognostic marker in human neuroblastoma. Moreover, B-myb expression has a prognostic value complementary to MYCN amplification and can identify a group of high-risk patients that would not be predicted on the basis of the MYCN status only.
Authors:
G Raschellà; V Cesi; R Amendola; A Negroni; B Tanno; P Altavista; G P Tonini; B De Bernardi; B Calabretta
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  59     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-08-12     Completed Date:  1999-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3365-8     Citation Subset:  IM    
Affiliation:
ENEA CR Casaccia, Section of Toxicology and Biomedical Sciences, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Cell Cycle Proteins*
Child
Child, Preschool
DNA-Binding Proteins / biosynthesis*
Follow-Up Studies
Gene Amplification*
Gene Expression Regulation, Neoplastic*
Genes, myc*
Humans
Infant
Infant, Newborn
Neuroblastoma / genetics*,  mortality,  pathology
Oncogenes*
Prognosis
Proportional Hazards Models
RNA, Messenger / biosynthesis,  genetics
RNA, Neoplasm / biosynthesis,  genetics
Reverse Transcriptase Polymerase Chain Reaction
Survival Analysis
Trans-Activators / biosynthesis*
Chemical
Reg. No./Substance:
0/Cell Cycle Proteins; 0/DNA-Binding Proteins; 0/MYBL2 protein, human; 0/RNA, Messenger; 0/RNA, Neoplasm; 0/Trans-Activators

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