| Expression of aryl hydrocarbon receptor in human placentas and fetal tissues. | |
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MedLine Citation:
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PMID: 20354149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, mediates many biological processes, including fetal development. In this study, we examined AhR protein expression in human placentas from normal (N) and severe preeclamptic (sPE) pregnancies, as well as human fetal tissues from the second trimester of pregnancy, using immunohistochemistry and/or Western blot analysis. In the placentas, the AhR immunoreactivity was present primarily in syncytiotrophoblasts. The AhR staining was also seen in endothelium of large blood vessels in villi and endothelium of umbilical cord arteries and veins. No difference in AhR protein levels was found between N and sPE placentas. In fetal tissues, the AhR immunoreactivity was localized in lung, kidney, esophagus, pancreas, liver, testicle, thymus gland, retina, and choroid, mainly in epithelial cells, whereas it was absent in heart, brain, sclera, and thoracic aorta. These findings suggest that the AhR plays a critical role in syncytiotrophoblasts of human placentas and epithelium of many fetal organs. These data also imply that human placentas and those fetal organs with high AhR expression (e.g., lung, kidney, liver, pancreas, and thymus gland) during fetal development are highly susceptible to environmental toxicants such as dioxin. |
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Authors:
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Yi-zhou Jiang; Kai Wang; Roy Fang; Jing Zheng |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-03-30 |
Journal Detail:
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Title: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society Volume: 58 ISSN: 1551-5044 ISO Abbreviation: J. Histochem. Cytochem. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-21 Completed Date: 2010-08-17 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 9815334 Medline TA: J Histochem Cytochem Country: United States |
Other Details:
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Languages: eng Pagination: 679-85 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI 53715, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blotting, Western Female Fetus / metabolism*, ultrastructure Gene Expression Regulation, Developmental* Humans Immunohistochemistry Placenta / metabolism*, ultrastructure Pregnancy Receptors, Aryl Hydrocarbon / genetics*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HD-38843/HD/NICHD NIH HHS; HL-64703/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Aryl Hydrocarbon |
| Comments/Corrections | |
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