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Expression Analysis of iPS Cell - Inductive Genes in Esophageal Squamous Cell Carcinoma by Tissue Microarray.
MedLine Citation:
PMID:  23225459     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
MATERIALS AND METHODS: The immunohistochemical expression levels of the five genes were compared to the clinicopathological data of the 81 patients with esophageal cancer.
RESULTS: There was no relationship between the expression of the five genes and TNM factors of the patients. High expression of NANOG was an independent favorable prognostic factor (p=0.041). Among the patients who received postoperative cisplatin-based chemotherapy, patients with NANOG-positive tumor had significantly better prognosis than those whose tumors were NANOG negative (p=0.024). On the other hand, those with c-MYC-positive expression tended to have a worse prognosis and were resistant to cisplatin-based chemotherapy.
CONCLUSION: NANOG expression was found to be an independent prognostic factor for patient with esophageal cancer. Patients with NANOG-positive expression tumor may be good candidates for cisplatin-based treatment.
Authors:
Yutaka Shimada; Tomoyuki Okumura; Shinichi Sekine; Makoto Moriyama; Shigeaki Sawada; Koshi Matsui; Isaku Yoshioka; Shozo Hojo; Toru Yoshida; Takuya Nagata; Junya Fukuoka; Kazuhiro Tsukada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  32     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  5507-14     Citation Subset:  IM    
Affiliation:
FACS, Department of Surgery & Science, Graduate School of Medicine & Pharmaceutical Sciences for Research, University of Toyama, Sugitani 2630, Toyama, 930-0194, Japan. yshimada@med.u-toyama.ac.jp.
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