| Expression Analysis of iPS Cell - Inductive Genes in Esophageal Squamous Cell Carcinoma by Tissue Microarray. | |
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MedLine Citation:
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PMID: 23225459 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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MATERIALS AND METHODS: The immunohistochemical expression levels of the five genes were compared to the clinicopathological data of the 81 patients with esophageal cancer. RESULTS: There was no relationship between the expression of the five genes and TNM factors of the patients. High expression of NANOG was an independent favorable prognostic factor (p=0.041). Among the patients who received postoperative cisplatin-based chemotherapy, patients with NANOG-positive tumor had significantly better prognosis than those whose tumors were NANOG negative (p=0.024). On the other hand, those with c-MYC-positive expression tended to have a worse prognosis and were resistant to cisplatin-based chemotherapy. CONCLUSION: NANOG expression was found to be an independent prognostic factor for patient with esophageal cancer. Patients with NANOG-positive expression tumor may be good candidates for cisplatin-based treatment. |
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Authors:
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Yutaka Shimada; Tomoyuki Okumura; Shinichi Sekine; Makoto Moriyama; Shigeaki Sawada; Koshi Matsui; Isaku Yoshioka; Shozo Hojo; Toru Yoshida; Takuya Nagata; Junya Fukuoka; Kazuhiro Tsukada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 32 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 5507-14 Citation Subset: IM |
Affiliation:
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FACS, Department of Surgery & Science, Graduate School of Medicine & Pharmaceutical Sciences for Research, University of Toyama, Sugitani 2630, Toyama, 930-0194, Japan. yshimada@med.u-toyama.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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