Document Detail


Expression Analysis of iPS Cell - Inductive Genes in Esophageal Squamous Cell Carcinoma by Tissue Microarray.
MedLine Citation:
PMID:  23225459     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
MATERIALS AND METHODS: The immunohistochemical expression levels of the five genes were compared to the clinicopathological data of the 81 patients with esophageal cancer.
RESULTS: There was no relationship between the expression of the five genes and TNM factors of the patients. High expression of NANOG was an independent favorable prognostic factor (p=0.041). Among the patients who received postoperative cisplatin-based chemotherapy, patients with NANOG-positive tumor had significantly better prognosis than those whose tumors were NANOG negative (p=0.024). On the other hand, those with c-MYC-positive expression tended to have a worse prognosis and were resistant to cisplatin-based chemotherapy.
CONCLUSION: NANOG expression was found to be an independent prognostic factor for patient with esophageal cancer. Patients with NANOG-positive expression tumor may be good candidates for cisplatin-based treatment.
Authors:
Yutaka Shimada; Tomoyuki Okumura; Shinichi Sekine; Makoto Moriyama; Shigeaki Sawada; Koshi Matsui; Isaku Yoshioka; Shozo Hojo; Toru Yoshida; Takuya Nagata; Junya Fukuoka; Kazuhiro Tsukada
Related Documents :
18413709 - Fine-tuning of hematopoietic stem cell homeostasis: novel role for ubiquitin ligase.
2846579 - Hormonal regulation of chimeric genes containing the phosphoenolpyruvate carboxykinase ...
19110619 - Short-term culture of human cd34+ cells for lentiviral gene transfer.
11296269 - In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermol...
11545619 - A packaging cell line generating cd4-specific retroviral vectors for efficient gene tra...
2299679 - Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral ve...
22847829 - Bisphenol-a affects the developmental progression and expression of heat-shock protein ...
24106459 - Insights on the functional interactions between mirnas and copy number variations in th...
18579779 - Epigenetic histone h3 lysine 9 methylation in metabolic memory and inflammatory phenoty...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  32     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  5507-14     Citation Subset:  IM    
Affiliation:
FACS, Department of Surgery & Science, Graduate School of Medicine & Pharmaceutical Sciences for Research, University of Toyama, Sugitani 2630, Toyama, 930-0194, Japan. yshimada@med.u-toyama.ac.jp.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Bevacizumab plus docetaxel and cisplatin for metastatic breast cancer: a pilot phase II study.
Next Document:  Distance to the neurooncological center: a negative prognostic factor in patients with glioblastoma ...