Document Detail


Expression of airway epithelial sodium channel in the preterm infant is related to respiratory distress syndrome but unaffected by repeat antenatal beta-methasone.
MedLine Citation:
PMID:  19776646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The airway epithelial sodium channel (ENaC) is rate limiting for postnatal alveolar fluid clearance. Increased lung water content is a feature of respiratory distress syndrome (RDS), which is reduced by antenatal corticosteroid treatment in preterm infants.
OBJECTIVES: Since corticosteroids also induce ENaC gene expression, we studied whether a repeat dose of antenatal beta-methasone affects postnatal expression of airway ENaC.
METHODS: 17 pregnant women with imminent preterm birth were randomized to receive a single repeat dose of beta-methasone (12 mg) or placebo (repeat beta-methasone: 8 infants, gestational age (GA) 30.8 +/- 2.2 weeks; placebo: 14 infants, GA 30.4 +/- 2.7 weeks). Expression of alpha-, beta- and gammaENaC subunits in nasal epithelium 1-5 and 20-29 h postnatally was analyzed with reverse transcription-PCR.
RESULTS: There were no differences between the study groups in RDS incidence or ENaC subunit expression (all p > 0.38). Regression coefficients for association of alphaENaC expression at 1-5 h with GA in infants with and without RDS differed significantly (p = 0.023). At 20-29 h, alphaENaC expression was lower in infants with RDS (p = 0.048).
CONCLUSIONS: A single repeat dose of antenatal beta-methasone did not increase ENaC expression, which may in part explain the absence of reduction in RDS incidence.
Authors:
Cecilia Janér; Otto Helve; Olli M Pitkänen; M Anneli Kari; Outi M Peltoniemi; Mikko Hallman; Petteri Hovi; Sture Andersson
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-09-22
Journal Detail:
Title:  Neonatology     Volume:  97     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2010  
Date Detail:
Created Date:  2010-02-05     Completed Date:  2010-04-22     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  132-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Betamethasone / administration & dosage*
Bronchopulmonary Dysplasia / drug therapy
Dose-Response Relationship, Drug
Epithelial Sodium Channels / genetics*
Female
Gene Expression / drug effects
Gestational Age
Glucocorticoids / administration & dosage*
Humans
Infant, Newborn
Infant, Premature / physiology*
Male
Nasal Mucosa / physiology
Pregnancy
Pulmonary Alveoli / physiology
Respiratory Distress Syndrome, Newborn / drug therapy*
Reverse Transcriptase Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/Epithelial Sodium Channels; 0/Glucocorticoids; 0/SCNN1A protein, human; 0/SCNN1B protein, human; 0/SCNN1G protein, human; 9842X06Q6M/Betamethasone

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