Document Detail

Expression of 3 beta-hydroxysteroid dehydrogenase/isomerase in the female rat pituitary.
MedLine Citation:
PMID:  10856887     Owner:  NLM     Status:  MEDLINE    
3 beta-Hydroxysteroid dehydrogenase/isomerase (3 beta-HSD) catalyses an essential step in the biosynthesis of steroid hormones and is widely distributed in peripheral steroid target organs. The present report describes for first time the expression of this enzyme in the pituitary of female rats. Immunohistochemistry at the light microscopic level was performed on pro-oestrous and ovariectomized rat pituitaries. Immunoreactive cells were scattered and randomly distributed throughout the anterior lobe, whereas cells located in the posterior lobe and pars intermedia were immunonegative. Differences were observed in cell morphology and in the number of 3 beta-HSD-immunopositive cells between ovariectomized and pro-oestrous female rat pituitaries, suggesting that steroidogenic activity is affected by ovarian endocrine function. Apart from adenohypophyseal immunoreactive cells, 3 beta-HSD immunopositivity was also noted in endothelial cells of almost all pituitary capillaries located in the anterior and posterior lobes.
S Vidal; A Roman; L Moya; K Kovacs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  166     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-17     Completed Date:  2000-08-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  95-101     Citation Subset:  IM    
Department of Anatomy, Laboratory of Histology, University of Santiago de Compostela, Lugo, Spain.
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MeSH Terms
3-Hydroxysteroid Dehydrogenases / metabolism*
Epithelium / enzymology
Pituitary Gland / enzymology*
Pituitary Gland, Anterior / enzymology
Pituitary Gland, Posterior / enzymology
Proestrus / metabolism*
Rats, Sprague-Dawley
Reg. No./Substance:
EC 1.1.-/3-Hydroxysteroid Dehydrogenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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