| Expression of 3 beta-hydroxysteroid dehydrogenase/isomerase in the female rat pituitary. | |
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MedLine Citation:
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PMID: 10856887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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3 beta-Hydroxysteroid dehydrogenase/isomerase (3 beta-HSD) catalyses an essential step in the biosynthesis of steroid hormones and is widely distributed in peripheral steroid target organs. The present report describes for first time the expression of this enzyme in the pituitary of female rats. Immunohistochemistry at the light microscopic level was performed on pro-oestrous and ovariectomized rat pituitaries. Immunoreactive cells were scattered and randomly distributed throughout the anterior lobe, whereas cells located in the posterior lobe and pars intermedia were immunonegative. Differences were observed in cell morphology and in the number of 3 beta-HSD-immunopositive cells between ovariectomized and pro-oestrous female rat pituitaries, suggesting that steroidogenic activity is affected by ovarian endocrine function. Apart from adenohypophyseal immunoreactive cells, 3 beta-HSD immunopositivity was also noted in endothelial cells of almost all pituitary capillaries located in the anterior and posterior lobes. |
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Authors:
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S Vidal; A Roman; L Moya; K Kovacs |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of endocrinology Volume: 166 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-08-17 Completed Date: 2000-08-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 95-101 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Laboratory of Histology, University of Santiago de Compostela, Lugo, Spain. svidal@lugo.usc.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxysteroid Dehydrogenases
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metabolism* Animals Epithelium / enzymology Female Immunohistochemistry Ovariectomy Pituitary Gland / enzymology* Pituitary Gland, Anterior / enzymology Pituitary Gland, Posterior / enzymology Proestrus / metabolism* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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EC 1.1.-/3-Hydroxysteroid Dehydrogenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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