Document Detail


Expression of 18-wheeler in the follicle cell epithelium affects cell migration and egg morphology in Drosophila.
MedLine Citation:
PMID:  16607637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Drosophila ovary is a model system for examining the genetic control of epithelial morphogenesis. The somatic follicle cells form a polarized epithelium surrounding the 16-cell germ line cyst. The integrity of this epithelium is essential for the successful completion of oogenesis. Reciprocal signaling between germ line and somatic cells establishes embryonic and eggshell polarity. The follicle cells are responsible for shaping the egg and secreting the eggshell. Follicle cells at the boundary between the nurse cells and the oocyte migrate centripetally to cover the anterior end of the oocyte and secrete the operculum. Dorsal anterior main body follicle cells undergo elaborate patterning to produce the dorsal appendages. We have examined the expression of the Toll-like receptor, 18-wheeler (18w), in the ovary and find it to be restricted to subpopulations of follicle cells. Females carrying loss-of-function 18w mutant clones in their ovaries show delayed follicle cell migrations. The eggs laid by such females also show morphological defects in egg shape and dorsal appendage morphology. We propose that the 18W protein plays an adhesive or signaling role in regions of the epithelium engaged in cell migration.
Authors:
Cassandra D Kleve; Dominic A Siler; Samreen K Syed; Elizabeth D Eldon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  235     ISSN:  1058-8388     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-08     Completed Date:  2006-10-24     Revised Date:  2008-07-07    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1953-61     Citation Subset:  IM    
Copyright Information:
(c) 2006 Wiley-Liss, Inc.
Affiliation:
California State University, Long Beach, Department of Biological Sciences, Long Beach, California 90840-3702, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Adhesion Molecules / genetics,  metabolism*
Cell Movement
Drosophila / metabolism,  physiology*
Drosophila Proteins / genetics,  metabolism*
Epithelial Cells / physiology*
Female
Membrane Proteins / genetics,  metabolism*
Mutation
Ovarian Follicle / metabolism,  physiology
Ovum / cytology*,  physiology
Signal Transduction
Chemical
Reg. No./Substance:
0/18w protein, Drosophila; 0/Cell Adhesion Molecules; 0/Drosophila Proteins; 0/Membrane Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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