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Expressed breast milk for procedural pain in preterm neonates: a randomized, double-blind, placebo-controlled trial.
MedLine Citation:
PMID:  23057434     Owner:  NLM     Status:  Publisher    
AIM: To determine if expressed breast milk (milk) reduces procedural pain associated with heel lancing in preterm neonates. METHODS: In this placebo-controlled trial, preterm neonates received 5 mL of distilled water as placebo (water, n = 44), 25% glucose water (glucose, n = 39), or milk (n = 40). Heel lancing was performed 2 minutes later. The primary outcome was the duration of first cry after lancing. RESULTS: Participants had similar baseline demographic and clinical characteristics. There was a significant difference in the median duration of first cry among the groups: water = 70.5 seconds (interquartile range [IQR] = 5.5-104.5); glucose = 2.0 seconds (IQR = 0.0-45.0); milk = 29.5 seconds (IQR = 0.0-65.0). Specifically, the duration of first cry was significantly shorter in the glucose group compared with the water group (Bonferroni adjustment, P = 0.011). Pain scores were significantly lower in the glucose and milk groups compared with the water group 1, 2, and 3 minutes after heel lancing (P<0.05). CONCLUSIONS: Although milk did not significantly reduce crying time, our finding that pain scores were significantly lower in the milk group suggests that milk may reduce pain associated with heel lancing in preterm neonates. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
Mei-Chen Ou-Yang; I-Lun Chen; Chih-Cheng Chen; Mei-Yung Chung; Feng-Shun Chen; Hsin-Chun Huang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
Division of Neonatology, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
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