| Exposures to airborne particulate matter and adverse perinatal outcomes: a biologically plausible mechanistic framework for exploring potential. | |
| | |
MedLine Citation:
|
PMID: 18813495 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
This article has three objectives: to describe the biologically plausible mechanistic pathways by which exposure to particulate matter (PM) may lead to adverse perinatal outcomes of low birth weight (LBW), intrauterine growth retardation (IUGR), and preterm delivery (PTD); review evidence showing that nutrition affects biologic pathways; and explain mechanisms by which nutrition may modify the impact of PM exposure on perinatal outcomes. We propose an interdisciplinary framework that brings together maternal and infant nutrition, air pollution exposure assessment, and cardiopulmonary and perinatal epidemiology. Five possible biologic mechanisms have been put forth in the emerging environmental sciences literature and provide corollaries for the proposed framework. The literature indicates that the effects of PM on LBW, PTD, and IUGR may manifest through the cardiovascular mechanisms of oxidative stress, inflammation, coagulation, endothelial function, and hemodynamic responses. PM exposure studies relating mechanistic pathways to perinatal outcomes should consider the likelihood that biologic responses and adverse birth outcomes may be derived from both PM and non-PM sources. We present strategies for empirically testing the proposed model and developing future research efforts. |
| | |
Authors:
|
Srimathi Kannan; Dawn P Misra; J Timothy Dvonch; Ambika Krishnakumar |
Related Documents
:
|
18797715 - Perinatal mortality in three population-based cohorts from southern brazil: trends and ... 9722055 - Retrospective analysis of causes of perinatal mortality in a polluted area. 5134885 - Morphologic correlates of age at death of infants with perinatal telencephalic leukoenc... 2452175 - Clinical and biochemical assessments of damage due to perinatal asphyxia: a double blin... 15496605 - Dysfunction of pulmonary surfactant in chronically ventilated premature infants. 23458265 - Newborn transepidermal water loss values: a reference dataset. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Ciência & saúde coletiva Volume: 12 ISSN: 1678-4561 ISO Abbreviation: Cien Saude Colet Publication Date: 2007 Nov-Dec |
Date Detail:
|
Created Date: 2008-09-24 Completed Date: 2008-12-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9713483 Medline TA: Cien Saude Colet Country: Brazil |
Other Details:
|
Languages: eng Pagination: 1591-602 Citation Subset: - |
Affiliation:
|
Department of Environmental Health Sciences, Human Nutrition Program, University of Michigan, School of Public Health, Ann Arbor, MI 48109-2029, USA. kannans@umich.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Comments/Corrections | |
Republished from:
|
Environ Health Perspect. 2006 Nov;114(11):1636-42
[PMID:
17107846
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Globalization, poverty and health
Next Document: Healthcare practices in Nursing and Communication: a review of the literature