| Exposures to Synthetic Estrogens at Different Times During the Life, and Their Effect on Breast Cancer Risk. | |
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MedLine Citation:
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PMID: 23392570 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Women are using estrogens for many purposes, such as to prevent pregnancy or miscarriage, or to treat menopausal symptoms. Estrogens also have been used to treat breast cancer which seems puzzling, since there is convincing evidence to support a link between high lifetime estrogen exposure and increased breast cancer risk. In this review, we discuss the findings that maternal exposure to the synthetic estrogen diethylstilbestrol during pregnancy increases breast cancer risk in both exposed mothers and their daughters. In addition, we review data regarding the use of estrogens in oral contraceptives and as postmenopausal hormone therapy and discuss the opposing effects on breast cancer risk based upon timing of exposure. We place particular emphasis on studies investigating how maternal estrogenic exposures during pregnancy increase breast cancer risk among daughters. New data suggest that these exposures induce epigenetic modifications in the mammary gland and germ cells, thereby causing an inheritable increase in breast cancer risk for multiple generations. |
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Authors:
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Leena Hilakivi-Clarke; Sonia de Assis; Anni Warri |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-8 |
Journal Detail:
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Title: Journal of mammary gland biology and neoplasia Volume: - ISSN: 1573-7039 ISO Abbreviation: J Mammary Gland Biol Neoplasia Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9601804 Medline TA: J Mammary Gland Biol Neoplasia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Oncology, Georgetown University, Washington, DC, USA, clarkel@georgetown.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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