Document Detail


Exposures to synthetic estrogens at different times during the life, and their effect on breast cancer risk.
MedLine Citation:
PMID:  23392570     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Women are using estrogens for many purposes, such as to prevent pregnancy or miscarriage, or to treat menopausal symptoms. Estrogens also have been used to treat breast cancer which seems puzzling, since there is convincing evidence to support a link between high lifetime estrogen exposure and increased breast cancer risk. In this review, we discuss the findings that maternal exposure to the synthetic estrogen diethylstilbestrol during pregnancy increases breast cancer risk in both exposed mothers and their daughters. In addition, we review data regarding the use of estrogens in oral contraceptives and as postmenopausal hormone therapy and discuss the opposing effects on breast cancer risk based upon timing of exposure. We place particular emphasis on studies investigating how maternal estrogenic exposures during pregnancy increase breast cancer risk among daughters. New data suggest that these exposures induce epigenetic modifications in the mammary gland and germ cells, thereby causing an inheritable increase in breast cancer risk for multiple generations.
Authors:
Leena Hilakivi-Clarke; Sonia de Assis; Anni Warri
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-02-08
Journal Detail:
Title:  Journal of mammary gland biology and neoplasia     Volume:  18     ISSN:  1573-7039     ISO Abbreviation:  J Mammary Gland Biol Neoplasia     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-08-19     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  9601804     Medline TA:  J Mammary Gland Biol Neoplasia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging*
Animals
Breast Neoplasms / chemically induced*,  metabolism,  prevention & control
Carcinogens / toxicity
Contraceptives, Oral, Hormonal / adverse effects
Diethylstilbestrol / adverse effects
Endocrine Disruptors / toxicity*
Environmental Exposure
Epigenesis, Genetic / drug effects
Estradiol Congeners / adverse effects*,  therapeutic use
Estrogen Replacement Therapy / adverse effects
Estrogens, Non-Steroidal / adverse effects
Female
Fetal Development / drug effects
Humans
Mammary Glands, Animal / drug effects
Mammary Glands, Human / drug effects*,  growth & development,  metabolism,  pathology
Maternal Exposure / adverse effects
Pregnancy
Risk
Grant Support
ID/Acronym/Agency:
P30 CA051668/CA/NCI NIH HHS; R01 CA164384/CA/NCI NIH HHS; R01 CA164384-01A1/CA/NCI NIH HHS; R03 CA150040/CA/NCI NIH HHS; U54 CA100970/CA/NCI NIH HHS; U54 CA100970/CA/NCI NIH HHS; U54 CA149147/CA/NCI NIH HHS; U54CA149147/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Contraceptives, Oral, Hormonal; 0/Endocrine Disruptors; 0/Estradiol Congeners; 0/Estrogens, Non-Steroidal; 731DCA35BT/Diethylstilbestrol
Comments/Corrections

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