Document Detail


Exposures of healthy and asthmatic volunteers to concentrated ambient ultrafine particles in Los Angeles.
MedLine Citation:
PMID:  18444007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adult volunteers (17 healthy, 14 asthmatic) were exposed in a controlled environmental chamber to concentrated ultrafine particles (UFP) collected in a Los Angeles suburb with substantial motor vehicle pollution. Exposures lasted 2 h with intermittent exercise. Inhaled particle counts (mean 145,000/cm(3), range 39,000-312,000) were typically 7-8 times higher than ambient levels. Mass concentrations (mean 100 microg/m(3), range 13-277) were not highly correlated with counts. Volunteers were evaluated for lung function, symptoms, exhaled nitric oxide (eNO), Holter electrocardiography, and inflammatory markers in peripheral blood and induced sputum. Relative to control (filtered air) studies, UFP exposures were associated with a 0.5% mean fall in arterial O(2) saturation estimated by pulse oximetry (p < .01), a 2% mean fall in forced expired volume in 1 sec (FEV(1)) the morning after exposure (p < .05), and a transient slight decrease in low-frequency (sympathetic) power in Holter recordings during quiet rest (p < .05). Healthy and asthmatic subjects were not significantly different across most endpoints. Thus, this initial experimental study of human volunteers exposed to concentrated Los Angeles area ambient UFP showed some acute deleterious cardiopulmonary responses, which, although generally small and equivocal as in previous studies of larger sized concentrated ambient particles, might help to explain reported adverse health effects associated with urban particulate pollution.
Authors:
Henry Gong; William S Linn; Kenneth W Clark; Karen R Anderson; Constantinos Sioutas; Neil E Alexis; Wayne E Cascio; Robert B Devlin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Inhalation toxicology     Volume:  20     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-29     Completed Date:  2008-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  533-45     Citation Subset:  IM    
Affiliation:
Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Asthma / chemically induced*
Blood Cell Count
Blood Chemical Analysis
Case-Control Studies
Electrocardiography, Ambulatory
Environmental Exposure
Female
Humans
Los Angeles
Male
Middle Aged
Nitric Oxide / metabolism
Oximetry
Particle Size
Particulate Matter / adverse effects*
Spirometry
Sputum / chemistry,  cytology
Grant Support
ID/Acronym/Agency:
5P30ES07048/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Particulate Matter; 10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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