Document Detail


Exposure to wood smoke particles produces inflammation in healthy volunteers.
MedLine Citation:
PMID:  21719562     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives Human exposure to wood smoke particles (WSP) impacts on human health through changes in indoor air quality, exposures from wild fires, burning of biomass and air pollution. This investigation tested the postulate that healthy volunteers exposed to WSP would demonstrate evidence of both pulmonary and systemic inflammation. Methods Ten volunteers were exposed to filtered air and, 3 weeks or more later, WSP. Each exposure included alternating 15 min of exercise and 15 min of rest for a total duration of 2 h. Wood smoke was generated by heating an oak log on an electric element and then delivered to the exposure chamber. Endpoints measured in the volunteers included symptoms, pulmonary function tests, measures of heart rate variability and repolarisation, blood indices and analysis of cells and fluid obtained during bronchoalveolar lavage. Results Mean particle mass for the 10 exposures to air and WSP was measured using the mass of particles collected on filters and found to be below the detectable limit and 485±84 μg/m(3), respectively (mean±SD). There was no change in either symptom prevalence or pulmonary function with exposure to WSP. At 20 h after wood smoke exposure, blood tests demonstrated an increased percentage of neutrophils, and bronchial and bronchoalveolar lavage revealed a neutrophilic influx. Conclusions We conclude that exposure of healthy volunteers to WSP may be associated with evidence of both systemic and pulmonary inflammation.
Authors:
Andrew J Ghio; Joleen M Soukup; Martin Case; Lisa A Dailey; Judy Richards; Jon Berntsen; Robert B Devlin; Susan Stone; Ana Rappold
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-30
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  -     ISSN:  1470-7926     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-7-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
The National Health and Environmental Effects Research Laboratory, US EPA, Research Triangle Park, North Carolina, USA.
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