Document Detail

Exposure to sibutramine during pregnancy.
MedLine Citation:
PMID:  17872638     Owner:  NLM     Status:  MEDLINE    
QUESTION: One of my patients who was taking sibutramine to lose weight found out that she had unexpectedly conceived. The medication was stopped as soon as she found out, about 5 weeks into the pregnancy. Is the baby at risk? Should the pregnancy be aborted?
ANSWER: No data to date suggest that involuntary exposure to sibutramine during pregnancy carries major risk of congenital malformations. Nevertheless, this medication should be avoided whenever possible during pregnancy, as there is little information on its effects.
Facundo Garcia-Bournissen; Alon Shrim; Gideon Koren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian family physician Médecin de famille canadien     Volume:  53     ISSN:  1715-5258     ISO Abbreviation:  Can Fam Physician     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-10-18     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  0120300     Medline TA:  Can Fam Physician     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  229-30     Citation Subset:  IM    
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MeSH Terms
Antidepressive Agents / adverse effects,  therapeutic use*
Cohort Studies
Cyclobutanes / adverse effects,  therapeutic use*
Infant, Newborn
Pregnancy Complications / drug therapy*,  psychology
Pregnancy Outcome*
Pregnancy Trimester, First
Risk Assessment
Reg. No./Substance:
0/Antidepressive Agents; 0/Cyclobutanes; WV5EC51866/sibutramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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