Document Detail

Exposure to second-hand smoke and reproductive outcomes depending on maternal asthma.
MedLine Citation:
PMID:  22323568     Owner:  NLM     Status:  MEDLINE    
Tobacco consumption and exposure to second-hand smoke (SHS) are associated with reduced birth weight. One issue that has not been clarified previously is that of the potential higher risk of this outcome in mothers with asthma. We assessed the role of prenatal maternal tobacco use and SHS on reproductive outcomes and assessed the interaction with maternal history of asthma. Data was collected from the INMA study, a maternal birth cohort selected from the general population established in Spain in 2002. We measured cotinine at the 32nd week of pregnancy in 2,219 females. Diagnosed maternal asthma was self-reported during pregnancy. 35% of mothers reported not being exposed to smoking or SHS during pregnancy. Active smoking (i.e. self-reported or cotinine >50 ng·mL(-1)) was related to a 134 g decrease in birth weight and a relative risk of 1.8 for small for gestational age and fetal growth restriction. These results were not modified by maternal asthma. Maternal asthma had a similar frequency in all exposure groups. Non SHS-exposed females had the lowest prevalence of asthma. SHS (i.e. cotinine 20-50 ng·mL(-1)) decreased birth weight by 32 g among those without maternal asthma, but these differences were not statistically significant (95% CI -88.76-24.76). Maternal asthma did not promote these effects. Maternal history of asthma did not modify the effects of smoking on reproductive outcomes in a cohort sampled from the general population.
Jordi Sunyer; Raquel Garcia-Esteban; Ane Miren Castilla; Juan José Aurrekoetxea; Carmen Iñiguez; Adonina Tardón; Mercedes Espada; Aitana Lertxundi; Leda Chatzi; Marisa Rebagliato; Manolis Kogevinas;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-09
Journal Detail:
Title:  The European respiratory journal     Volume:  40     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-02     Completed Date:  2013-01-10     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  371-6     Citation Subset:  IM    
Centre for Research in Environmental Epidemiology, Barcelona, Spain.
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MeSH Terms
Asthma / complications*,  epidemiology,  etiology*
Birth Weight
Cohort Studies
Cotinine / urine
Gestational Age
Infant, Newborn
Maternal Exposure
Pregnancy Complications
Pregnancy Outcome
Smoking / adverse effects
Tobacco Smoke Pollution*
Treatment Outcome
Reg. No./Substance:
0/Tobacco Smoke Pollution; 486-56-6/Cotinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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