Document Detail


Exposure to professional pest control treatments and the risk of childhood acute lymphoblastic leukemia.
MedLine Citation:
PMID:  21080443     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Previous studies suggest that exposure to pesticides increases the risk of childhood acute lymphoblastic leukemia (ALL). The aim of this analysis was to investigate whether professional pest treatments in or around the home before birth or during childhood increased the risk of childhood ALL. Data from 388 cases and 870 frequency-matched controls were analyzed using unconditional logistic regression, adjusting for study matching variables and potential confounders, to calculate odds ratios (ORs). A meta-analysis of our findings with the published findings of previous studies was also conducted. The ORs for any professional pest control treatments were 1.19 (95% CI 0.83, 1.69) in the year before pregnancy, 1.30 (95% CI 0.86, 1.97) during pregnancy and 1.24 (95% CI 0.93, 1.65) for those done after the child's birth. The ORs for exposure after birth were highest when it occurred between the ages of two and three years. ORs were elevated for termite treatments before birth. ORs were higher for pre-B than T cell ALL and for t(12;21) (ETV6-Runx-1) than other cytogenetic sub-types. The pooled OR from a meta-analysis of our study with three previous studies of professional pest control treatments during pregnancy was 1.37 (95% CI 1.00, 1.88). Our results, and those of our meta-analysis, provide some evidence of a modestly increased risk of ALL for professional pest control treatments done during the index pregnancy and possibly in the child's early years. The analysis of pooled data from international collaborations may provide more certainty regarding these potentially important associations.
Authors:
Helen D Bailey; Bruce K Armstrong; Nicholas H de Klerk; Lin Fritschi; John Attia; Rodney J Scott; Elizabeth Smibert; Elizabeth Milne;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-11
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  129     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-07-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1678-88     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 UICC.
Affiliation:
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia. helenb@ichr.uwa.edu.au
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MeSH Terms
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Investigator
Investigator/Affiliation:
Bruce K Armstrong / ; Elizabeth Milne / ; Frank M van Bockxmeer / ; Michelle Haber / ; Rodney J Scott / ; John Attia / ; Murray D Norris / ; Carol Bower / ; Nicholas H de Klerk / ; Lin Fritschi / ; Ursula R Kees / ; Margaret Miller / ; Judith R Thompson / ; Helen D Bailey / ; Frank Alvaro / ; Catherine Cole / ; Luciano Dalla Pozza / ; John Daubenton / ; Peter Downie / ; Liane Lockwood / ; Maria Kirby / ; Glenn Marshall / ; Elizabeth Smibert / ; Ram Suppiah /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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