Document Detail

Exposure to passive smoking: a test to predict endothelial dysfunction and atherosclerotic lesions.
MedLine Citation:
PMID:  18403462     Owner:  NLM     Status:  MEDLINE    
Acute exposure to environmental tobacco smoke (ETS) is considered to adversely influence atherogenesis. The aim of this article was to assess whether brachial ultrasonography in subjects with endothelial dysfunction after ETS exposure is associated with atherosclerotic lesions. Never smoker healthy volunteers (n = 18) and subjects with a previous myocardial infarction (MI; n = 10) were studied. Healthy volunteers were 12 men (66%) and 6 women (34%) with a mean age of 34 +/- 9 years. Post-MI subjects were men with a mean age of 53.8 +/- 4.8 years. After assessing endothelial function (by brachial ultrasonography) at rest, study subjects underwent brachial ultrasonography twice: in a smoke-free environment and then in the same environment polluted by cigarette combustion (35 ppm carbon monoxide concentration). Carboxyhemoglobin concentration was measured before and after ETS exposure. Baseline brachial-artery diameter, diameter during reactive hyperemia, and diameter after sublingual nitroglycerin (GTN) administration (endothelium-independent vasodilator) were measured at rest and in both smoke-free and smoking environments. Each study subject acted as their own control. No comparison was made between the two groups. A strong correlation between ETS exposure and endothelial dysfunction was observed in both groups. Post-MI subjects also showed endothelium-independent vasodilation worsening, which is usually due to arterial wall alterations. After ETS exposure, mean flow-mediated vasodilation after GTN was significantly (P < .01) reduced only in post-MI subjects (P < .01). Carboxyhemoglobin concentration increased in both groups (P < .01). ETS exposure may be an effective test to identify endothelial dysfunction and arterial wall alterations by using brachial ultrasonography.
Aurelio Leone; Alberto Balbarini
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angiology     Volume:  59     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:    2008 Apr-May
Date Detail:
Created Date:  2008-04-11     Completed Date:  2008-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  220-3     Citation Subset:  IM    
Cardiothoracic Department, University of Pisa, Pisa, Italy.
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MeSH Terms
Atherosclerosis / physiopathology*
Brachial Artery / physiopathology,  ultrasonography*
Carboxyhemoglobin / analysis
Case-Control Studies
Endothelium, Vascular / physiopathology*
Middle Aged
Myocardial Infarction / physiopathology
Nitroglycerin / administration & dosage
Regional Blood Flow / physiology
Tobacco Smoke Pollution / adverse effects*
Vasodilation / physiology
Vasodilator Agents / administration & dosage
Reg. No./Substance:
0/Tobacco Smoke Pollution; 0/Vasodilator Agents; 55-63-0/Nitroglycerin; 9061-29-4/Carboxyhemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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