| Exposure to nitrogen dioxide is not associated with vascular dysfunction in man. | |
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MedLine Citation:
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PMID: 20047363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Exposure to air pollution is associated with increased cardiorespiratory morbidity and mortality. It is unclear whether these effects are mediated through combustion-derived particulate matter or gaseous components, such as nitrogen dioxide. OBJECTIVES: To investigate the effect of nitrogen dioxide exposure on vascular vasomotor and six fibrinolytic functions. METHODS: Ten healthy male volunteers were exposed to nitrogen dioxide at 4 ppm or filtered air for 1 h during intermittent exercise in a randomized double-blind crossover study. Bilateral forearm blood flow and fibrinolytic markers were measured before and during unilateral intrabrachial infusion of bradykinin (100-1000 pmol/min), acetylcholine (5-20 microg/min), sodium nitroprusside (2-8 microg/min), and verapamil (10-100 microg/min) 4 h after the exposure. Lung function was determined before and after the exposure, and exhaled nitric oxide at baseline and 1 and 4 h after the exposure. RESULTS: There were no differences in resting forearm blood flow after either exposure. There was a dose-dependent increase in forearm blood flow with all vasodilators but this was similar after either exposure for all vasodilators (p > .05 for all). Bradykinin caused a dose-dependent increase in plasma tissue-plasminogen activator, but again there was no difference between the exposures. There were no changes in lung function or exhaled nitric oxide following either exposure. CONCLUSION: Inhalation of nitrogen dioxide does not impair vascular vasomotor or fibrinolytic function. Nitrogen dioxide does not appear to be a major arbiter of the adverse cardiovascular effects of air pollution. |
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Authors:
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Jeremy P Langrish; Magnus Lundb?ck; Stefan Barath; Stefan S?derberg; Nicholas L Mills; David E Newby; Thomas Sandstr?m; Anders Blomberg |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Inhalation toxicology Volume: 22 ISSN: 1091-7691 ISO Abbreviation: Inhal Toxicol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-18 Completed Date: 2010-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8910739 Medline TA: Inhal Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 192-8 Citation Subset: IM |
Affiliation:
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Centre for Cardiovascular Sciences, University of Edinburgh, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Air Pollutants, Occupational / metabolism, toxicity* Blood Cell Count Cross-Over Studies Double-Blind Method Endothelium, Vascular / drug effects, pathology Exercise / physiology Fibrinolysis / drug effects Hemodynamics / drug effects Humans Inhalation Exposure Lung / drug effects Male Nitrogen Dioxide / metabolism, toxicity* Oxidants, Photochemical / metabolism, toxicity* Plasminogen Activators / metabolism Respiratory Function Tests Spirometry Thrombosis / blood Vascular Diseases / chemically induced*, epidemiology, pathology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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FS/07/048//British Heart Foundation |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants, Occupational; 0/Oxidants, Photochemical; 10102-44-0/Nitrogen Dioxide; EC 3.4.21.-/Plasminogen Activators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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