| Exposure to nanoparticle-rich diesel exhaust may cause liver damage. | |
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MedLine Citation:
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PMID: 21996760 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Diesel exhaust (DE) is one of the air pollutants in the world, and exposure to DE is an environmental health concern. Most studies amongst the limited number of studies on hepatotoxicity have focused on genotoxicity or mutagenicity. However, DE exposure may cause liver damage because one prospective study suggests that DE exposure is associated with increased mortality due to arteriosclerosis and cirrhosis of the liver. Peroxisome proliferator-activated receptor (PPAR) α plays a role in the regulation of lipid homeostasis and inflammation and thereby may be involved in the progression of atherosclerosis. We investigated whether nanoparticle-rich diesel exhaust (NR-DE) affects the liver and how PPARα is involved in the NR-DE induced effects. We report these results briefly in this minireview. Our results suggest NR-DE-induced hepatic inflammation and dyslipidemia. PPARα may be involved in the development of these disorders. |
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Authors:
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Yuki Ito; Doni Hikmat Ramdhan; Yukie Yanagiba; Nozomi Yamagishi; Michihiro Kamijima; Tamie Nakajima |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nihon eiseigaku zasshi. Japanese journal of hygiene Volume: 66 ISSN: 0021-5082 ISO Abbreviation: Nihon Eiseigaku Zasshi Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-10-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417457 Medline TA: Nihon Eiseigaku Zasshi Country: Japan |
Other Details:
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Languages: eng Pagination: 638-42 Citation Subset: IM |
Affiliation:
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Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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