Document Detail

Exposure to manganese: health effects on the general population, a pilot study in central Mexico.
MedLine Citation:
PMID:  11161659     Owner:  NLM     Status:  MEDLINE    
To support a risk assessment of manganese exposure in two communities living within a manganese mining district a cross-sectional study was performed on a sample of the adult population of long-term residents. One community was exposed to a point source from an ore primary refining plant. Manganese is an essential mineral for human life. It is also the fourth in importance for industrial metal making. Data were collected on socioeconomic living conditions, emission sources, environmental media concentrations (air, water, soil, dust, food), respiratory symptomatology, and a neuropsychological examination (Mini-Mental Screening test, the Hooper Visual Organization test, the Ardila-Ostroski, and others). We examined 73 subjects (52 women), most of low socioeconomic status. Environmental air concentrations were 2 to 3 times higher than those in other urban concentrations. Manganese blood concentrations ranged from 7.5 to 88 microg/L, with a median concentration of 15, the upper quartile starting at 20 microg/L; the upper 10% was above 25 microg/L. Lead and manganese were highly correlated; there was an inverse relation to hemoglobin. Reduced levels of plasma lipid peroxidation were associated with blood manganese. Using multivariate logistic regression, we identified B-Mn as increasing the risk of deficient cognitive performance 12 times (Mini-Mental score of less than 17).
C Santos-Burgoa; C Rios; L A Mercado; R Arechiga-Serrano; F Cano-Valle; R A Eden-Wynter; J L Texcalac-Sangrador; J P Villa-Barragan; Y Rodriguez-Agudelo; S Montes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental research     Volume:  85     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-104     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Instituto de Salud Ambiente y Trabajo, Cerrada del Convento 48-A, Colonia Santa Ursula Xitla, Tlalpan, D.F. c.p. 14420, Mexico.
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MeSH Terms
Aged, 80 and over
Cognition Disorders / chemically induced*
Cross-Sectional Studies
Environmental Exposure*
Lead / adverse effects,  blood
Lipid Peroxidation
Manganese / adverse effects*,  blood
Middle Aged
Pilot Projects
Public Health*
Risk Assessment
Social Class
Urban Population
Reg. No./Substance:
7439-92-1/Lead; 7439-96-5/Manganese

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