Document Detail

Exposure to intermittent high altitude induces different changes in adenylyl cyclase activity in hearts of young and adult Wistar rats.
MedLine Citation:
PMID:  12680589     Owner:  NLM     Status:  MEDLINE    
This study investigates changes of adenylyl cyclase activity in the heart of young and adult Wistar rats exposed to experimental conditions simulating high altitude hypoxia as a model for interpretation of some adaptive changes of adenylyl cyclase observed in human. The exposure of rats to intermittent high altitude (IHA) hypoxia (5000 m) showed significant adaptive changes. The right ventricular weight and the ratio of right/left ventricular weights of adult rats exposed to IHA were significantly increased when compared to appropriate controls; adaptive changes of cardiac adenylyl cyclase being dependent on the age of the animals. The isoprenaline-stimulated activity was higher in the left than in the right ventricle, and in both ventricles it was higher in young rats than in adult rats. When compared to controls, isoprenaline stimulation was decreased in the right ventricles of adapted young rats and, by contrast, it was increased in the left ventricles of adapted adult rats. This decrease and increase of adenylyl cyclase activity evoked by isoprenaline was paralleled by forskolin-induced adenylyl cyclase activity in these experimental groups. It seems therefore that the changes in the pattern of total adenylyl cyclase activity observed under IHA hypoxia may at least be partially explained by the changes of beta-adrenergic receptor susceptibility following IHA hypoxia.
S Hynie; P Sída; V Klenerová; G Asemu; B Ost'ádal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of receptor and signal transduction research     Volume:  23     ISSN:  1079-9893     ISO Abbreviation:  J. Recept. Signal Transduct. Res.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-04-08     Completed Date:  2003-11-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9509432     Medline TA:  J Recept Signal Transduct Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  53-67     Citation Subset:  IM    
Charles University in Prague, First Faculty of Medicine, Department of Pharmacology, Prague, Czech Republic.
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MeSH Terms
Adaptation, Physiological
Adenylate Cyclase / metabolism*
Altitude Sickness / enzymology,  pathology
Anoxia / enzymology,  pathology
Enzyme Activation / drug effects
Forskolin / pharmacology
Heart Ventricles / enzymology,  pathology
Isoproterenol / pharmacology
Myocardium / enzymology*
Organ Size
Rats, Wistar
Reg. No./Substance:
66428-89-5/Forskolin; 7683-59-2/Isoproterenol; EC Cyclase

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