Document Detail

Exposure to high dosage trihexyphenidyl during pregnancy for treatment of generalized dystonia: case report and literature review.
MedLine Citation:
PMID:  22045287     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Trihexyphenidyl is 1 of the most effective agents for treatment of young-onset dystonia. As such, women of childbearing potential use trihexyphenidyl despite inadequate information about potential effects on pregnancy, labor, and fetal development.
CASE REPORT: We report 2 uncomplicated pregnancies in 1 woman with early-onset, sporadic, primary generalized dystonia (DYT1 negative) treated with high dosage trihexyphenidyl and review the literature on antidystonic agents and pregnancy.
CONCLUSION: Although there is limited data, our case demonstrates that high-dosage trihexyphenidyl treatment is not necessarily a contraindication to pregnancy.
Bradley James Robottom; Stephen G Reich
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The neurologist     Volume:  17     ISSN:  2331-2637     ISO Abbreviation:  Neurologist     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-02     Completed Date:  2012-02-23     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  9503763     Medline TA:  Neurologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  340-1     Citation Subset:  IM    
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MeSH Terms
Antiparkinson Agents / therapeutic use*
Child, Preschool
Dystonic Disorders / drug therapy*
Pregnancy Outcome
Trihexyphenidyl / therapeutic use*
Reg. No./Substance:
0/Antiparkinson Agents; 6RC5V8B7PO/Trihexyphenidyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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