Document Detail

Exposure to hexanal odor influences maternal behavior and induces neonatal death in Fyn tyrosine kinase-deficient mice.
MedLine Citation:
PMID:  15154672     Owner:  NLM     Status:  MEDLINE    
Fyn-deficient pups born of Fyn-deficient parents die because they fail to suckle within 1-2 days after birth. Here we demonstrate that the neonatal death phenotype was influenced by the genetic background and an environmental odor. The odor of hexanal (C6-aldehyde) partially impaired mouse maternal behavior and induced the neonatal death of Fyn-deficient pups born of Fyn-deficient parents. This death phenotype was first observed in the breeding environment using autoclaved chips of Douglas fir. An analysis of the volatile chemicals in the autoclaved chips revealed an approximately 10-fold greater amount of hexanal than in non-autoclaved chips. Hexanal influenced the length of time virgin female mice engage in the maternal crouching behavior. In addition, Fyn-deficient females exhibited defects in the maternal behavior of nest building and pup retrieval, regardless of exposure to hexanal. These observations provide new insights into the regulation of maternal behavior by environmental and genetic factors.
Kayoko Hamaguchi-Hamada; Chiaki Sanbo; Shun Hamada; Takeshi Yagi
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience research     Volume:  48     ISSN:  0168-0102     ISO Abbreviation:  Neurosci. Res.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-05-24     Completed Date:  2004-07-06     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  259-67     Citation Subset:  IM    
KOKORO Biology Group, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, Yamadaoka 1-3, Suita 565-0871, Japan.
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MeSH Terms
Aldehydes / toxicity*
Behavior, Animal / drug effects
Birth Rate
Gas Chromatography-Mass Spectrometry / methods
Insecticides / toxicity*
Maternal Behavior / drug effects*
Mice, Inbred C57BL
Mice, Knockout
Prenatal Exposure Delayed Effects*
Proto-Oncogene Proteins / deficiency*,  genetics
Proto-Oncogene Proteins c-fyn
Reaction Time
Statistics, Nonparametric
Survival Rate
Time Factors
Reg. No./Substance:
0/Aldehydes; 0/Insecticides; 0/Proto-Oncogene Proteins; 66-25-1/n-hexanal; EC protein, mouse; EC Proteins c-fyn

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